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A Double-blind Study Comparing an Acellular Pertussis—Component DTP Vaccine With a Whole-Cell Pertussis—Component DTP Vaccine in 18-Month-Old Children

Karen Lewis, MD; James D. Cherry, MD; H. James Holroyd, MD; Leonard R. Baker, MD; Frank E. Dudenhoeffer, MD; Ricki G. Robinson, MD
Am J Dis Child. 1986;140(9):872-876. doi:10.1001/archpedi.1986.02140230042025.
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• An acellular pertussis—component diphtheria-tetanus-pertussis (AC-DTP) vaccine was compared with a currently licensed, whole-cell pertussis—component DTP (WC-DTP) vaccine for reactogenicity and immunogenicity when given as the fourth DTP immunization in sixty 18- to 24-month-old children. Reactions over the first 48 hours were significantly less common in the AC-DTP vaccine recipients, as follows (WC-DTP/AC-DTP): fever, 85%/5%; redness, 70%/12.5%; tenderness, 100%/22.5%; swelling, 35%/10%; fretfulness, 70%/12.5%; anorexia, 35%/2.5%; and vomiting, 10%/0%. Antibody responses to pertussis antigens (agglutinogens, lymphocytosis-promoting factor, and filamentous hemagglutinin), diphtheria toxoid, and tetanus toxoid in AC-DTP vaccine recipients were comparable with those in WC-DTP vaccine recipients. The AC-DTP vaccine evaluated in this trial seems to be as immunogenic as WC-DTP vaccine while being markedly less reactogenic.

(AJDC 1986;140:872-876)

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