0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Vancomycin Pharmacokinetics in Neonates

J. MICHAEL SPIVEY; PETER GAL, PHARMD
Am J Dis Child. 1986;140(9):859. doi:10.1001/archpedi.1986.02140230029020.
Text Size: A A A
Published online

Sir.—We read with interest the article by Naqvi et al1 regarding vancomycin pharmacokinetics in neonates. We would like to focus on the important effect of indomethacin use on vancomycin disposition in neonates. We have treated numerous neonates with vancomycin for Staphylococcus epidermidis infections. Each neonate receives a vancomycin loading dose of 15 to 20 mg/kg administered intravenously over one hour. A postloading dose peak and trough serum concentration value are obtained before the first maintenance dose is given. Pharmacokinetic variables, volume of distribution, and half-life are then calculated using a one-compartment pharmacokinetic model.

Eleven neonates with postconceptional ages of less than 35 weeks are the subject of this letter. The group was subdivided into six neonates with patent ductus arteriosus (PDA) treated with indomethacin and five control neonates without PDA who did not receive indomethacin. The characteristics of the neonates and their vancomycin pharmacokinetic variables are summarized in

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();