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August 1986, Vol 140, No. 8 >
Article | August 1986

Familial Sexual Precocity FREE

REUBEN ROHN, MD; Gus ROUSONELOS, MD
Am J Dis Child. 1986;140(8):741-742. doi:10.1001/archpedi.1986.02140220023017.
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Sir.—Dr Ruvalcaba's letter concerning the rarity of familial isosexual precocity in females intrigued us, since anecdotally our experience was different.1 We then reviewed the charts of 58 girls in whom isosexual precocious puberty had been diagnosed. They were all seen in our endocrine clinic over the past six years. Three girls (5.2%) had family histories indicating that other family members had also experienced sexual precocity.

Patient Reports.—Patient 1.—A girl aged 7 years 11 months had onset of breast development at age 6 years and pubic hair development at 7½ years of age. Her height age was 11½ years. Breast and pubic hair development were each at Tanner stage III. Her bone age was 11½ years. Laboratory values included: follicle-stimulating hormone (FSH), 3.2 mIU/mL (IU/L); luteinizing hormone (LH), 4.7 mIU/mL (IU/L) (prepubertal normal levels for each, 5 mIU/mL [IU/L]); and estradiol, 58 pg/mL (213 pmol/L) (prepubertal normal,

REFERENCES

1 +
Ruvalcaba RHA:  Isosexual precocious puberty . AJDC 1985;;139:1179-1180.
2 +
Hopwood NJ, Kelch RP, Helder LJ:  Familial precocious puberty in a brother and sister . AJDC 1981;;135:78-79.
3 +
Steven-Simons C, Forbes G, McAnarney E:  What does gynecologic age measure? J Adolesc Health Care 1985;;6:340.
4 +
Johnston FE:  Control of age at menarche . Hum Biol 1974;;46:159-171.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Ruvalcaba RHA:  Isosexual precocious puberty . AJDC 1985;;139:1179-1180.
2 +
Hopwood NJ, Kelch RP, Helder LJ:  Familial precocious puberty in a brother and sister . AJDC 1981;;135:78-79.
3 +
Steven-Simons C, Forbes G, McAnarney E:  What does gynecologic age measure? J Adolesc Health Care 1985;;6:340.
4 +
Johnston FE:  Control of age at menarche . Hum Biol 1974;;46:159-171.

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