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June 1986, Vol 140, No. 6 >
Article | June 1986

Narcotic Withdrawal Syndrome in Young Adults After the Therapeutic Use of Opiates FREE

Angela W. Miser, MBBS; Karen J. Chayt, MD; John T. Sandlund, MD; Pamela S. Cohen, MD; Judith A. Dothage, RN; James S. Miser, MD
[+] Author Affiliations

Accepted for publication Feb 9, 1986.

Reprint requests to Pediatric Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Room 13N240, Bethesda, MD 20892 (Dr Miser).


Am J Dis Child. 1986;140(6):603-604. doi:10.1001/archpedi.1986.02140200113039.
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• Five young adults with malignant neoplasms developed symptoms of narcotic withdrawal six to 48 hours after the abrupt discontinuation of narcotic therapy that had been administered for six to 21 days. The symptoms, which included agitation, irritability, muscular jerks, abdominal pain, diarrhea, burning sensations, "gooseflesh," and itching, rapidly resolved when narcotic therapy was reinstituted. Four patients were then successfully weaned from opiates without recurrence of their withdrawal symptoms; the fifth patient continues to receive methadone hydrochloride treatment for continuing pain.

(AJDC 1986;140:603-604)

REFERENCES

1 +
Cobrinik RW, Hood RT Jr, Chusid E:  The effect of maternal narcotic addiction on the newborn infant: Review of the literature and report of 22 cases . Pediatrics 1959;;24:288-304.
2 +
Pruitt AW, Anyan WR, Hill RM, et al:  Neonatal drug withdrawal . Pediatrics 1983;;72: 895-902.
3 +
Kanner RM, Foley KM:  Patterns of narcotic drug use in a cancer pain clinic . Ann NY Acad Sci 1981;;362:161-172.
4 +
Hasday JD, Weintraub M:  Propoxyphene in children with iatrogenic morphine dependence . AJDC 1983;;137:745-748.
5 +
Simantov R, Snyder SH:  Elevated levels of enkephalin in morphine-dependent rats . Nature 1976;;262:505-507.
6 +
Jaffe JH:  Drug addiction and drug abuse , in Gilman AG, Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics . New York, Macmillan Publishing Co Inc, 1980;, pp 535-584.
7 +
Sharma SK, Klee WA, Nirenberg M:  Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance . Proc Natl Acad Sci USA 1975;;72:3092-3096.
8 +
Bird SJ, Kuhar MJ:  Iontophoretic application of opiates to the locus coeruleus . Brain Res 1977;;122:523-533.
9 +
Cedarbaum JM, Aghajanian GK:  Catecholamine receptors on locus coeruleus neurons: Pharmacologic characterization . Eur J Pharmacol 1977;;44:375-385.
10 +
Wahlstrom A, Terenius L:  Factor in human CSF with apparent morphine-antagonistic properties . Acta Physiol Scand 1980;;110:427-429.
11 +
Martin WR, Eades CG:  Demonstration of tolerance and physical dependence in the dog following a short-term infusion of morphine . J Pharmacol Exp Ther 1961;;133:262-270.
12 +
Washton AM, Resnick RB, Rawson RA:  Clonidine for outpatient opiate detoxification . Lancet 1980;;1:1078-1079.
13 +
Gold MS, Pottash AC, Sweeney DR, et al:  Opiate withdrawal using clonidine . JAMA 1980;; 243:343-346.

Figures

Tables

Interactive Graphics

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Cobrinik RW, Hood RT Jr, Chusid E:  The effect of maternal narcotic addiction on the newborn infant: Review of the literature and report of 22 cases . Pediatrics 1959;;24:288-304.
2 +
Pruitt AW, Anyan WR, Hill RM, et al:  Neonatal drug withdrawal . Pediatrics 1983;;72: 895-902.
3 +
Kanner RM, Foley KM:  Patterns of narcotic drug use in a cancer pain clinic . Ann NY Acad Sci 1981;;362:161-172.
4 +
Hasday JD, Weintraub M:  Propoxyphene in children with iatrogenic morphine dependence . AJDC 1983;;137:745-748.
5 +
Simantov R, Snyder SH:  Elevated levels of enkephalin in morphine-dependent rats . Nature 1976;;262:505-507.
6 +
Jaffe JH:  Drug addiction and drug abuse , in Gilman AG, Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics . New York, Macmillan Publishing Co Inc, 1980;, pp 535-584.
7 +
Sharma SK, Klee WA, Nirenberg M:  Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance . Proc Natl Acad Sci USA 1975;;72:3092-3096.
8 +
Bird SJ, Kuhar MJ:  Iontophoretic application of opiates to the locus coeruleus . Brain Res 1977;;122:523-533.
9 +
Cedarbaum JM, Aghajanian GK:  Catecholamine receptors on locus coeruleus neurons: Pharmacologic characterization . Eur J Pharmacol 1977;;44:375-385.
10 +
Wahlstrom A, Terenius L:  Factor in human CSF with apparent morphine-antagonistic properties . Acta Physiol Scand 1980;;110:427-429.
11 +
Martin WR, Eades CG:  Demonstration of tolerance and physical dependence in the dog following a short-term infusion of morphine . J Pharmacol Exp Ther 1961;;133:262-270.
12 +
Washton AM, Resnick RB, Rawson RA:  Clonidine for outpatient opiate detoxification . Lancet 1980;;1:1078-1079.
13 +
Gold MS, Pottash AC, Sweeney DR, et al:  Opiate withdrawal using clonidine . JAMA 1980;; 243:343-346.

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