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June 1986, Vol 140, No. 6 >
Article | June 1986

Intracranial Hemorrhage in Patients With Sickle Cell Disease FREE

AHMAD A. MALLOUH, MD; JAHED A. HAMDAN, MD
Am J Dis Child. 1986;140(6):505-506. doi:10.1001/archpedi.1986.02140200015011.
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Sir.—In their recent article van Hoff et al1 failed to mention a special group of patients with sickle cell disease who have a characteristic syndrome of post-transfusion hypertension, seizures, and intracranial hemorrhage. We2 reported three children (aged 6, 10, and 12 years, respectively) with this syndrome. Two children developed the three components of the syndrome (hypertension, seizure, and intracranial hemorrhage); a spinal tap was not done on the third child. Royal and Seeler3 reported two children (aged 8 and 14 years, respectively) with the syndrome; one child had intracranial hemorrhage while the other child had normal cerebrospinal fluid. The only adult patient reported with this syndrome had hypertension and seizures but no intracranial hemorrhage.4 A similar syndrome was reported by Wasi et al5 in patients with thalassemia major.

The pathogenesis is not known; however, it might be multifactorial. Release of a vasopressor substance from

REFERENCES

1 +
van Hoff J, Ritchey AK, Shaywitz BA:  Intracranial hemorrhage in children with sickle cell disease . AJDC 1985;;139:1120-1123.
2 +
Hamdan J, Mallouh AA, Ahmad MS:  Hypertension and convulsions complicating sickle cell anemia: Possible role of transfusion . Ann Trop Paediatr 1984;;4:41-43.
3 +
Royal JE, Seeler RA:  Hypertension convulsions and cerebral hemorrhage in sickle cell anemia patients after blood transfusion . Lancet 1978;;2:1207.
4 +
Warth JA:  Hypertension and seizure following transfusion in an adult with sickle cell anemia . Arch Intern Med 1984;;144:607-608.
5 +
Wasi P, Pootrakul P, Piankijagum A, et al:  A syndrome of hypertension, convulsion, and cerebral hemorrhage in thalassemic patients after multiple blood transfusions . Lancet 1978;;2: 602-604.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
van Hoff J, Ritchey AK, Shaywitz BA:  Intracranial hemorrhage in children with sickle cell disease . AJDC 1985;;139:1120-1123.
2 +
Hamdan J, Mallouh AA, Ahmad MS:  Hypertension and convulsions complicating sickle cell anemia: Possible role of transfusion . Ann Trop Paediatr 1984;;4:41-43.
3 +
Royal JE, Seeler RA:  Hypertension convulsions and cerebral hemorrhage in sickle cell anemia patients after blood transfusion . Lancet 1978;;2:1207.
4 +
Warth JA:  Hypertension and seizure following transfusion in an adult with sickle cell anemia . Arch Intern Med 1984;;144:607-608.
5 +
Wasi P, Pootrakul P, Piankijagum A, et al:  A syndrome of hypertension, convulsion, and cerebral hemorrhage in thalassemic patients after multiple blood transfusions . Lancet 1978;;2: 602-604.

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