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Further Reports of Urinary Tract Involvement in EEC Syndrome

Am J Dis Child. 1986;140(5):411. doi:10.1001/archpedi.1986.02140190021012.
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Sir.—With interest I read the article by London et al1 about urinary tract involvement in ectrodactyly, ectodermal dysplasia, and cleft lip and/or palate (EEC) syndrome, in which the authors pointed out the importance of a urinary tract examination in patients with EEC syndrome. They described their own observations and four cases of EEC syndrome with renal anomalies they found reported in the literature. There are at least ten further reports of EEC syndrome and urinary tract involvement (Table).2-11 In the first six listed cases, there existed a typical EEC syndrome. The patient with EEC described by Preus and Fraser8 suffered from ectrodactyly and ectodermal dysplasia, but the cleft lip and palate were missing. The last three patients9-11 showed additional clinical features that are not associated with the EEC syndrome, including congenital skin defects,9 congenital skin defects and epidermolysis bullosa, 10 and prune-belly syndrome.11


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