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Penicillin Treatment of Streptococcal Pharyngitis-Reply

MICHAEL A. GERBER, MD
Am J Dis Child. 1986;140(5):410-411. doi:10.1001/archpedi.1986.02140190019011.
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In Reply.—Drs Ball, Nelson, and Mayefsky are correct in their observation that the power of our study1 did not preclude the possibility of a type II or β error.2 We would agree that our study alone does not have sufficient power to definitely conclude that there is no difference between the two treatment regimens. However, as noted in our report,1 there have been five similar investigations, none of which could demonstrate a statistically significant difference between BID and TID penicillin treatments. We were therefore careful to note our conclusion, which stated that oral penicillin V given BID is as effective as oral penicillin V given TID for the treatment of group A β-hemolytic streptococcal pharyngitis with respect to bacteriologic-treatment failures, was based on "the results of this and earlier investigations."1

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