April 1986, Vol 140, No. 4 >

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Article | April 1986

Genetic Polymorphism and Intrauterine Development: The Role of Maternal PGM1 and MNSs Genotypes

FULVIA GLORIA-BOTTINI; NAZZARENO LUCARINI; ENEA BONCI; FRANCESCO PASCASIO; MARCO BONCI; MARCELLO ASSUMMA; ANTONIO SCALAMANDRÉ; EGIDIO BOTTINI

Am J Dis Child. 1986;140(4):324-326. doi:10.1001/archpedi.1986.02140180058013.

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Sir.—In a study on the possible role of genetic polymorphisms in the etiology of unexplained habitual abortion, we have observed a significant relation between the gestational duration of aborted fetuses and both maternal phosphoglucomutase locus 1 (PGM₁) and Ss genotypes.¹ Aborted fetuses from mothers with the PGM₁ 2-1 genotype and those from mothers with the SS genotype showed a longer gestational duration as compared with fetuses from mothers with other PGM₁ and Ss genotypes, respectively. Genotype distributions of these two polymorphisms in couples with habitual abortion were also statistically different from distributions in a control population. These observations prompted us to search for possible effects of maternal PGM₁ and Ss genotypes on the gestational duration in normal pregnancies.

A consecutive series of 142 women who were delivered of a single liveborn infant was studied. Through the use of standard techniques, the MNSs genotype was determined

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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GLORIA-BOTTINI F, LUCARINI N, BONCI E, et al. Genetic Polymorphism and Intrauterine Development: The Role of Maternal PGM1 and MNSs Genotypes. Am J Dis Child. 1986;140(4):324-326. doi:10.1001/archpedi.1986.02140180058013.

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