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Clonidine and Growth Hormone Response-Reply

Am J Dis Child. 1986;140(3):187-188. doi:10.1001/archpedi.1986.02140170012005.
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In Reply.—This is in reply to the letter of Englehart and his colleagues, who report their experience with clonidine as a stimulus for GH release and conclude that smaller dosages of clonidine (below 100 μg/sq m of surface area [SA]) are insufficient to provoke an adequate GH response in healthy, short children. Such data are in agreement with our experience.1 Since the publication of our report, we have screened 21 other children with short stature by the administration of a tablet of 100 μg of clonidine hydrochloride and by obtaining a single blood sample for the GH level at 60 minutes. With this simple screening test, we found that of 14 children who received 100 μg or more of clonidine hydrochloride per square meter of SA, five failed the test (serum GH level lower than 8.0 ng/mL). On the other hand, none of the seven patients who received


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