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March 1986, Vol 140, No. 3 >
Article | March 1986

Clonidine and Growth Hormone Response

JAY ENGLEHART; JONATHAN JENSEN, MD; BARRY GARFINKEL, MD; JOSEPH SOCKALOSKY, MD
Am J Dis Child. 1986;140(3):186-187. doi:10.1001/archpedi.1986.02140170012004.
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Sir.—Lanes et al1 reported in AJDC that 64% of normal growth hormone (GH) secretors responded to an oral dose of 50 μg of clonidine hydro

chloride, whereas 90% of a similar group of children responded to 100 μg of clonidine hydrochloride. This statistically significant difference conflicts with two previously published letters, which indicated that a dose as low as 25 μg produced an adequate GH response in the pediatric age group.2,3

Our results (Table) support the conclusions of Lanes and his colleagues. When we administered an oral dose of 25 μg if the child weighed under 47.5 kg and 50 μg if the child was over this weight, only three of 12 normal boys between the ages of 10 and 16 years had an unambiguous response to clonidine. This compares with seven of 12 who responded to 500 mg of levodopa. The order of drug administration was

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
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