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Intracranial Hemorrhage in Premature Infants

WILLIAM C. HANIGAN, MD, PHD; WILLIAM F. POWERS, MD; GAIL KENNEDY, MD; FRANK ROEMISCH, MD
Am J Dis Child. 1986;140(3):184. doi:10.1001/archpedi.1986.02140170010001.
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Sir.—Meidell et al1 have shown that of 40 premature infants, representing all inborn patients admitted to their service over a 12-month period, 15 (38%) experienced an intracranial hemorrhage (ICH) at a mean time of 1.9 hours after birth. The SE of the mean was 0.2 hours, which suggests that the hemorrhages were clustered into a reasonably small range. While their data may be accurate, we feel that it may not be representative of other investigators' observations.

We have been conducting a study involving all admissions to our highrisk nursery over the past ten months.

In that period, 94 infants weighing less than 1,500 g were admitted and received sonograms within 12 hours. Five (5.3%) of the infants (three inborn) had sustained an ICH. Two previous studies2,3 demonstrated that only 5% to 10% of all admissions hemorrhaged within 12 hours. A fourth study,4 which entered alternate patients and included

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