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Article |

Restoration of Suppressor T-Cell Functions in Children With AIDS Following Intravenous Gamma Globulin Treatment

Asha Gupta, MD; Brian E. Novick, MD; Arye Rubinstein, MD
Am J Dis Child. 1986;140(2):143-146. doi:10.1001/archpedi.1986.02140160061033.
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• Suppressor T-cell function was analyzed in seven children with acquired autoimmunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). Four of the patients had markedly increased serum IgG levels. All patients had elevated percentages and absolute numbers of peripheral blood T8 cells. In vitro concanavalin A generation of suppressor cells for T-cell mitogenic responses and suppression of pokeweed mitogendriven immunoglobulin secretion were diminished in all patients. After intravenous treatment with gamma globulin, four patients regained in vitro suppression of pokeweed mitogen-driven gamma globulin secretion. Treatment with intravenous gamma globulin also modified in vitro suppressor T-cell functions in children with AIDS or ARC.

(AJDC 1986;140:143-146)


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