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December 1985, Vol 139, No. 12 >
Article | December 1985

isosexual Precocious Puberty FREE

R. H. A. RUVALCABA, MD
Am J Dis Child. 1985;139(12):1179-1180. doi:10.1001/archpedi.1985.02140140013008.
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Sir.—To my knowledge, there is only one report of sexual precocity affecting sisters.1 Siblings of mixed sexes have been reported.2-4 This report is of a father and two daughters with isosexual precocious puberty.

Patients and Methods.—The first patient was seen at the age of 7.5 years, with rapid growth first noted at age 5.5 years associated with breast buds. At age 6 years, pubic hair developed and she used deodorants at age 6.5 years. Axillary hair and menses had not been noted at 7.5 years. No neurologic disorder was present.

Her height was 143 cm (height age, 11 years) and she weighed 41 kg. Breasts were at Tanner stage III-IV, the axillae were moist without hair, and pubic hair was Tanner stage III. The clitoris was not enlarged and the labial mucosa was estrogenized. Two flat hemangiomata were present on the anterior abdomen (4×2 cm) and

REFERENCES

1 +
Hampson JG, Money J:  Idiopathic sexual precocity in the female: Report of three cases . Psychosom Med 1955;;17:16-18.
2 +
Frasier SD, Brenner PF:  Familial complete precocious puberty affecting both sexes . AJDC 1982;;136:560-561.
3 +
Ferrier P, Shepard TH, Smith EK:  Growth disturbances and values for hormone excretion in various forms of precocious sexual development . Pediatrics 1961;;28:258-275.
4 +
Hapwood NJ, Kelch RP, Helder LJ:  Familial precocious puberty in a brother and sister . AJDC 1981;;135:78-79.
5 +
Egli CA, Rosenthal SM, Grumbach MM, et al:  Pituitary gonadotropin-independent malelimited autosomal dominant sexual precocity in nine generations: Familial testotoxicosis . J Pediatr 1985;;106:33-40.

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References

1 +
Hampson JG, Money J:  Idiopathic sexual precocity in the female: Report of three cases . Psychosom Med 1955;;17:16-18.
2 +
Frasier SD, Brenner PF:  Familial complete precocious puberty affecting both sexes . AJDC 1982;;136:560-561.
3 +
Ferrier P, Shepard TH, Smith EK:  Growth disturbances and values for hormone excretion in various forms of precocious sexual development . Pediatrics 1961;;28:258-275.
4 +
Hapwood NJ, Kelch RP, Helder LJ:  Familial precocious puberty in a brother and sister . AJDC 1981;;135:78-79.
5 +
Egli CA, Rosenthal SM, Grumbach MM, et al:  Pituitary gonadotropin-independent malelimited autosomal dominant sexual precocity in nine generations: Familial testotoxicosis . J Pediatr 1985;;106:33-40.

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