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Twice-Daily Penicillin in the Treatment of Streptococcal Pharyngitis

Michael A. Gerber, MD; Linda J. Spadaccini, RN; Laura L. Wright; Larry Deutsch, MD; Edward L. Kaplan, MD
Am J Dis Child. 1985;139(11):1145-1148. doi:10.1001/archpedi.1985.02140130083035.
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• An investigation was performed to compare the effectiveness of oral penicillin V given twice daily with penicillin V given three times daily in the treatment of group A βhemolytic streptococcal (GABHS) pharyngitis. Patients were randomly assigned to receive 250 mg of penicillin V either two or three times daily for ten days. Overall, 23 (23%) of 99 patients had the same strain of GABHS isolated from their follow-up as from their initial throat culture and were considered to have bacteriologic-treatment failures. Of the 50 patients in the three-times-daily group, nine (18%) had bacteriologic-treatment failures, while 14 (28.5%) of 49 patients in the twice-daily group had bacteriologic-treatment failures. The results of this and earlier investigations suggest that penicillin V given twice daily is as effective as penicillin V given three times daily for the treatment of GABHS pharyngitis.

(AJDC 1985;139:1145-1148)

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