In Reply.—We appreciate the commentaries by Drs Laron and Gil-Ad and apologize for omitting their studies in our report. We are, however, somewhat surprised by their findings which showed that 11 of 12 children exhibited a good growth hormone response after only 25 μg of oral clonidine. Our experience with children of similar age was quite different. As we reported, only nine (64%) of 14 children exhibited an adequate growth hormone response with a higher dose (50 μg) of clonidine than that used by Drs Laron and Gil-Ad. We do not have any explanation for the discrepancies between our results and those of Drs Laron and Gil-Ad. Since their patients were given insulin tolerance tests at various times prior to the administration of clonidine, the actual possibility of "priming" the response with insulin could be considered.
We felt that a dose of oral clonidine measuring 100 μg/sq m of