0
October 1985, Vol 139, No. 10 >
Article | October 1985

QTc and R-R Intervals in Victims of the Sudden Infant Death Syndrome FREE

Steven L. Weinstein, MD; Alfred Steinschneider, MD, PhD
[+] Author Affiliations

Reprint requests to American Sudden Infant Death Syndrome Institute, 275 Carpenter Dr, Atlanta, GA 30328 (Dr Steinschneider).


Am J Dis Child. 1985;139(10):987-990. doi:10.1001/archpedi.1985.02140120033023.
Text Size: A A A
Published online
Article
References
Comments

• Electrocardiograms obtained during sleep within the first and/or fourth week postnatally were available on eight infants who subsequently died of the sudden infant death syndrome (SIDS). The corrected QT (QTc) and R-R intervals were compared with controls for the purpose of evaluating their relevance for SIDS. The QTc interval in controls increased with age and tended to be longer during sleep without rapid eye movements. The R-R interval decreased with age. None of the SIDS victims was found to have a prolonged QTc interval. However, the R-R interval during rapid eye movement epochs was significantly shorter in future SIDS victims compared with controls. These data were interpreted as being inconsistent with the congenital variants of the long-QT hypothesis but compatible with the growing conviction that infants who die of SIDS have a chronic underlying abnormality that has subtle manifestations within the immediate postnatal period.

(AJDC 1985;139:987-990)

REFERENCES

1 +
Valdes-Dapena MA:  Sudden infant death syndrome: A review of the medical literature, 1974-1979 . Pediatrics 1980;;66:597-614.
2 +
Schwartz PJ:  The sudden infant death syndrome , in Scarpelli EM, Cosmi EV (eds): Reviews in Perinatal Medicine . New York, Raven Press, 1981;, vol 14, pp 475-524.
3 +
Guntheroth WG:  The QT interval and sudden infant death syndrome . Circulation 1982;;66: 502-504.
4 +
Schwartz PJ:  Autonomic nervous system, ventricular fibrillation, and SIDS , in Tildon JT, Roeder LM, Steinschneider A (eds): Sudden Infant Death Syndrome . New York, Academic Press Inc, 1983;, pp 319-339.
5 +
Southall DP, Richards JM, deSwiet M, et al:  Identification of infants destined to die unexpectedly during infancy: Evaluation of predictive importance of prolonged apnea and disorders of cardiac rhythm or conduction . Br Med J 1983;;286: 1092-1096.
6 +
Schwartz PJ, Montemerlo M, Facchini M, et al:  The QT interval throughout the first six months of life: A prospective study . Circulation 1982;;66:496-501.
7 +
Steinschneider A, Weinstein SL, Diamond E:  The sudden infant death syndrome and apnea/obstruction during neonatal sleep and feeding . Pediatrics 1982;;70:858-863.
8 +
Steinschneider A:  Sudden infant death syndrome and prolongation of the QT interval . AJDC 1978;;132:688-691.
9 +
Haddad GG, Epstein MAE, Epstein RA, et al:  The QT interval in aborted sudden infant death syndrome infants . Pediatr Res 1979;;13: 136-138.
10 +
Ostwald PF, Phibbs R, Fox S:  Diagnostic use of infant cry . Biol Neonate 1968;;13:68-82.
11 +
Anderson RB, Rosenblith JF:  Sudden unexpected death syndrome: Early indicators . Biol Neonate 1971;;18:395-406.
12 +
Stark RE, Nathanson SN:  Unusual features of cry in an infant dying suddenly and unexpectedly , in Bosma JF, Showacre J (eds): Symposium on Development of Upper Respiratory Anatomy and Function: Implication for Sudden Infant Death Syndrome . Washington DC, 1975;, US Dept of Health, Education, and Welfare, pp 233-248.
13 +
Anderson-Huntington RB, Rosenblith JF:  Central nervous system damage as a possible component of unexpected death in infancy . Dev Med Child Neurol 1976;;18:480-492.
14 +
Naeye RL, Ladis B, Drage JS:  Sudden infant death syndrome: A prospective study . AJDC 1976;;130:1207-1210.
15 +
Colton RH, Steinschneider A:  The cry characteristics of an infant who died of the sudden infant death syndrome . J Speech Hear Disord 1981;;46:359-363.
16 +
Golub HL, Corwin MJ:  Infant cry: A clue to diagnosis . Pediatrics 1982;;69:197-201.
17 +
Heinz JM, Stark RE, Condino R, et al: Acoustic analysis of cry of SIDS infants. Read before the 106th meeting of the Acoustical Society of America, San Diego, Nov 11, 1983.
18 +
Alimeurung MM, Joseph LG, Craige E, et al:  The QT interval in normal infants and children . Circulation 1950;;1:1329-1337.
19 +
Haddad GG, Krongrad E, Epstein RA, et al:  Effect of sleep stage on the QT interval in normal infants . Pediatr Res 1979;;13:139-141.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Valdes-Dapena MA:  Sudden infant death syndrome: A review of the medical literature, 1974-1979 . Pediatrics 1980;;66:597-614.
2 +
Schwartz PJ:  The sudden infant death syndrome , in Scarpelli EM, Cosmi EV (eds): Reviews in Perinatal Medicine . New York, Raven Press, 1981;, vol 14, pp 475-524.
3 +
Guntheroth WG:  The QT interval and sudden infant death syndrome . Circulation 1982;;66: 502-504.
4 +
Schwartz PJ:  Autonomic nervous system, ventricular fibrillation, and SIDS , in Tildon JT, Roeder LM, Steinschneider A (eds): Sudden Infant Death Syndrome . New York, Academic Press Inc, 1983;, pp 319-339.
5 +
Southall DP, Richards JM, deSwiet M, et al:  Identification of infants destined to die unexpectedly during infancy: Evaluation of predictive importance of prolonged apnea and disorders of cardiac rhythm or conduction . Br Med J 1983;;286: 1092-1096.
6 +
Schwartz PJ, Montemerlo M, Facchini M, et al:  The QT interval throughout the first six months of life: A prospective study . Circulation 1982;;66:496-501.
7 +
Steinschneider A, Weinstein SL, Diamond E:  The sudden infant death syndrome and apnea/obstruction during neonatal sleep and feeding . Pediatrics 1982;;70:858-863.
8 +
Steinschneider A:  Sudden infant death syndrome and prolongation of the QT interval . AJDC 1978;;132:688-691.
9 +
Haddad GG, Epstein MAE, Epstein RA, et al:  The QT interval in aborted sudden infant death syndrome infants . Pediatr Res 1979;;13: 136-138.
10 +
Ostwald PF, Phibbs R, Fox S:  Diagnostic use of infant cry . Biol Neonate 1968;;13:68-82.
11 +
Anderson RB, Rosenblith JF:  Sudden unexpected death syndrome: Early indicators . Biol Neonate 1971;;18:395-406.
12 +
Stark RE, Nathanson SN:  Unusual features of cry in an infant dying suddenly and unexpectedly , in Bosma JF, Showacre J (eds): Symposium on Development of Upper Respiratory Anatomy and Function: Implication for Sudden Infant Death Syndrome . Washington DC, 1975;, US Dept of Health, Education, and Welfare, pp 233-248.
13 +
Anderson-Huntington RB, Rosenblith JF:  Central nervous system damage as a possible component of unexpected death in infancy . Dev Med Child Neurol 1976;;18:480-492.
14 +
Naeye RL, Ladis B, Drage JS:  Sudden infant death syndrome: A prospective study . AJDC 1976;;130:1207-1210.
15 +
Colton RH, Steinschneider A:  The cry characteristics of an infant who died of the sudden infant death syndrome . J Speech Hear Disord 1981;;46:359-363.
16 +
Golub HL, Corwin MJ:  Infant cry: A clue to diagnosis . Pediatrics 1982;;69:197-201.
17 +
Heinz JM, Stark RE, Condino R, et al: Acoustic analysis of cry of SIDS infants. Read before the 106th meeting of the Acoustical Society of America, San Diego, Nov 11, 1983.
18 +
Alimeurung MM, Joseph LG, Craige E, et al:  The QT interval in normal infants and children . Circulation 1950;;1:1329-1337.
19 +
Haddad GG, Krongrad E, Epstein RA, et al:  Effect of sleep stage on the QT interval in normal infants . Pediatr Res 1979;;13:139-141.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems