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Increased Urinary Excretion of Renal Glucosaminidase in Hypercalciuria

F. Bruder Stapleton, MD; Russell W. Chesney, MD; Ann T. Behrmann, MD; Leslie A. Miller
Am J Dis Child. 1985;139(9):950-952. doi:10.1001/archpedi.1985.02140110104041.
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• Urinary excretion of N-acetyl-β-glucosaminidase (NAG), a lysosomal enzyme, was examined In 33 children with hypercalciuria. Urinary NAG excretion In 13 healthy children was 5.84±9.35 nmole/hr/mg of creatinine (NAG/Cr) (mean±SD) compared with 35.61±42.04 nmole/hr/mg of creatinine in 23 children with renal hypercalciuria, and 28.99 ±13.69 nmole/hr/mg of creatinine In ten children with absorptive hypercalciuria. In children with renal hypercalciuria, NAG/Cr excretion was not statistically different between children with either urolithiasis or hematuria without calculi. In six children with renal hypercalciuria, no significant change in NAG/Cr excretion occurred after a mean duration of 25 weeks of hydrochlorothiazide therapy although urinary calcium to creatinine ratios (UCa/Cr) decreased from 0.24±0.11 to 0.16±0.11. We conclude that increased urinary calcium excretion produces renal tubular injury and that the renal injury may not be reversed by short-term alterations in urinary calcium excretion.

(AJDC 1985;139:950-952)


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