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July 1985, Vol 139, No. 7 >
Article | July 1985

Amyloidosis as a Complication of Cystic Fibrosis FREE

Robert Castile, MD; Harry Shwachman, MD; William Travis, MD; Cynthia A. Hadley, MD; Warren Warwick, MD; H. P. Missmahl, MD
[+] Author Affiliations

Reprint requests to Division of Respiratory Diseases, The Children's Hospital, 300 Longwood Ave, Boston, MA 02115 (Dr Castile).


Am J Dis Child. 1985;139(7):728-732. doi:10.1001/archpedi.1985.02140090090040.
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References
Comments

•Amyloidosis appears to be a rare complication of cystic fibrosis. We discuss three patients with amyloidosis complicating cystic fibrosis to add to the six patients previously recorded. The presenting problem was proteinuria in five patients, thyromegaly in three patients, and hepatosplenomegaly in one patient. The progression of proteinuria to nephrotic syndrome and edema occurred in eight of nine patients and octended a very poor prognosis. The kidneys, adrenal glands, spleen, thyroid gland, liver, heart, and bowel were most frequently involved. Renal involvement is a frequent and devastating complication of amyloidosis in patients with cystic fibrosis.

(AJDC 1985;139:728-732)

REFERENCES

1 +
Glenner GG:  Amyloid deposits and amyloidosis . N Engl J Med 1980;;302:1283-1292, 1333-1343.
2 +
Kyle RA, Greipp PR:  Amyloidosis . Mayo Clin Proc 1983;;58:665-683.
3 +
Wiman L, Hofer P:  Amyloidosis and lung diseases . Eur J Respir Dis 1974;;55:5-18.
4 +
Brownstein MH, Helwig EB:  Secondary systemic amyloidosis: Analysis of underlying disorders . South Med J 1971;;64:491-496.
5 +
Missmahl HP:  Amyloidose: Clinic, Therapie, prognose : Fortschr Med 1967;;85:621-623.
6 +
Ristow SC, Condemi JJ, Stuard ID, et al:  Systemic amyloidosis in cystic fibrosis . AJDC 1977;;131:886-888.
7 +
Prior J, Crawford AD:  Systemic amyloidosis complicating cystic fibrosis . Br J Dis Chest 1980;; 74:84-86.
8 +
Vilaseca J, Cuevas J, Fresmo M, et al:  Systemic amyloidosis in cystic fibrosis . AJDC 1981;;135:667.
9 +
Carretero Sastre JL, Fernández JMA, del Campo MF, et al:  Una rara asociación: Fibrosis quistica y amiloidosis sistémica . Rev Clin Esp 1983;;169:273-275.
10 +
Biberstein M, Wolf P, Pettross B, et al:  Amyloidosis complicating cystic fibrosis . Am J Clin Pathol 1983;;80:752-754.
11 +
Callís L:  Nefropatías en las colagenosis . An Esp Pediatr 1981;;15:90-94.
12 +
Landing BH:  Comments on pathologic aspects of fibrocystic disease . Ann NY Acad Sci 1962;;93:518-525.
13 +
Esterly JR, Oppenheimer EH, Landing BH:  Pathology of cystic fibrosis , in Mangos JA, Talmos RC (eds): Cystic Fibrosis: Projections Into the Future . New York, Stratton Intercontinental Medical Book Corp, 1976;, p 117.
14 +
Abramowsky CR, Swinehart GL:  The nephropathy of cystic fibrosis . Hum Pathol 1982;; 13:934-939.
15 +
Vawter GF, Shwachman H:  Cystic fibrosis in adults . Pathol Annu 1979;;14( (pt 2) ):357-382.
16 +
Lowenstein J, Gallo G:  Remission of the nephrotic syndrome in renal amyloidosis . N Engl J Med 1970;;282:128-132.
17 +
Dikman SH, Kahn T, Gribetz D, et al:  Resolution of renal amyloidosis . Am J Med 1977;; 63:430-433.
18 +
Falck HM, Tornroth T, Skrifvars B, et al:  Resolution of renal amyloidosis secondary to rheumatoid arthritis . Acta Med Scand 1979;;205: 651-656.
19 +
Cohen AS, Calkins E, Mullinax PF:  Studies in experimental amyloidosis: III. The effect of cortisone administration on the incidence of casein-induced amyloidosis in the rabbit . Arch Intern Med 1962;;110:569-573.
20 +
Maxwell MH, Adams DA, Goldman R:  Corticosteroid therapy of amyloid nephrotic syndrome . Ann Intern Med 1964;;60:539-555.
21 +
Jones NF:  Renal amyloidosis: Pathogenesis and therapy . Clin Nephrol 1976;;6:459-464.
22 +
Cohen AS:  An update of clinical, pathologic, and biochemical aspects of amyloidosis . Int J Dermatol 1981;;20:515-530.

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References

1 +
Glenner GG:  Amyloid deposits and amyloidosis . N Engl J Med 1980;;302:1283-1292, 1333-1343.
2 +
Kyle RA, Greipp PR:  Amyloidosis . Mayo Clin Proc 1983;;58:665-683.
3 +
Wiman L, Hofer P:  Amyloidosis and lung diseases . Eur J Respir Dis 1974;;55:5-18.
4 +
Brownstein MH, Helwig EB:  Secondary systemic amyloidosis: Analysis of underlying disorders . South Med J 1971;;64:491-496.
5 +
Missmahl HP:  Amyloidose: Clinic, Therapie, prognose : Fortschr Med 1967;;85:621-623.
6 +
Ristow SC, Condemi JJ, Stuard ID, et al:  Systemic amyloidosis in cystic fibrosis . AJDC 1977;;131:886-888.
7 +
Prior J, Crawford AD:  Systemic amyloidosis complicating cystic fibrosis . Br J Dis Chest 1980;; 74:84-86.
8 +
Vilaseca J, Cuevas J, Fresmo M, et al:  Systemic amyloidosis in cystic fibrosis . AJDC 1981;;135:667.
9 +
Carretero Sastre JL, Fernández JMA, del Campo MF, et al:  Una rara asociación: Fibrosis quistica y amiloidosis sistémica . Rev Clin Esp 1983;;169:273-275.
10 +
Biberstein M, Wolf P, Pettross B, et al:  Amyloidosis complicating cystic fibrosis . Am J Clin Pathol 1983;;80:752-754.
11 +
Callís L:  Nefropatías en las colagenosis . An Esp Pediatr 1981;;15:90-94.
12 +
Landing BH:  Comments on pathologic aspects of fibrocystic disease . Ann NY Acad Sci 1962;;93:518-525.
13 +
Esterly JR, Oppenheimer EH, Landing BH:  Pathology of cystic fibrosis , in Mangos JA, Talmos RC (eds): Cystic Fibrosis: Projections Into the Future . New York, Stratton Intercontinental Medical Book Corp, 1976;, p 117.
14 +
Abramowsky CR, Swinehart GL:  The nephropathy of cystic fibrosis . Hum Pathol 1982;; 13:934-939.
15 +
Vawter GF, Shwachman H:  Cystic fibrosis in adults . Pathol Annu 1979;;14( (pt 2) ):357-382.
16 +
Lowenstein J, Gallo G:  Remission of the nephrotic syndrome in renal amyloidosis . N Engl J Med 1970;;282:128-132.
17 +
Dikman SH, Kahn T, Gribetz D, et al:  Resolution of renal amyloidosis . Am J Med 1977;; 63:430-433.
18 +
Falck HM, Tornroth T, Skrifvars B, et al:  Resolution of renal amyloidosis secondary to rheumatoid arthritis . Acta Med Scand 1979;;205: 651-656.
19 +
Cohen AS, Calkins E, Mullinax PF:  Studies in experimental amyloidosis: III. The effect of cortisone administration on the incidence of casein-induced amyloidosis in the rabbit . Arch Intern Med 1962;;110:569-573.
20 +
Maxwell MH, Adams DA, Goldman R:  Corticosteroid therapy of amyloid nephrotic syndrome . Ann Intern Med 1964;;60:539-555.
21 +
Jones NF:  Renal amyloidosis: Pathogenesis and therapy . Clin Nephrol 1976;;6:459-464.
22 +
Cohen AS:  An update of clinical, pathologic, and biochemical aspects of amyloidosis . Int J Dermatol 1981;;20:515-530.

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