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Sulfisoxazole Prophylaxis of Middle Ear Effusion and Recurrent Acute Otitis Media

Izhak Varsano, MD; Benjamin Volovitz, MD; Francis Mimouni, MD
Am J Dis Child. 1985;139(6):632-635. doi:10.1001/archpedi.1985.02140080102044.
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• The efficacy of sulfisoxazole prophylaxis was evaluated in 32 otitls-prone children in a double-blind cross-over clinical trial. During the sulfisoxazole therapy, seven patients (22%) had nine episodes of acute otitis media (AOM) while 20 patients (63%) receiving placebo had 36 episodes of AOM (P=.001). Although sulfisoxazole appeared to be beneficial in patients aged 2 to 5 years, statistically significant efficacy was noted only In children under 2 years of age. Otitis media with effusion persisting for more than five weeks was observed in ten children (31%) during sulfisoxazole therapy and in 14 children (44%) during the placebo period (P>.975). Sulfisoxazole therefore appears effective In preventing recurrent symptomatic AOM but not in reducing the frequency of persistent otitis media with effusion. The importance of careful follow-up of children receiving long-term sulfisoxazole therapy for prevention of recurrent AOM is stressed.

(AJDC 1985;139:632-635)


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