This issue of AJDC contains an article by Listernick et al1 that compares two regimens of oral hydration solutions given to mildly ill infants with diarrheal disease. The patients were selected because they were not dehydrated by clinical criteria when they were entered in the study. The results showed that a solution with 60 mEq/L of sodium and 111 mmole/L of glucose was effective and that one with 30 mEq/L of sodium and 267 mmole/L of glucose sometimes produced hyponatremia. These are both observations that have been made before, though not necessarily in simultaneously treated groups. A number of studies similar to this one are appearing in the literature all over the world at present. Many of them, like this one, are sound within the design, but do not ask an important question and they tend to duplicate what has already been demonstrated.
Most of the studies are flawed in