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May 1985, Vol 139, No. 5 >
Article | May 1985

Factors Influencing Adolescents' Responses to Regimens of Naproxen for Dysmenorrhea FREE

Robert H. DuRant, MA; M. Susan Jay, MD; Tamsen Shoffitt, RN; Charles W. Linder, MD; William Taylor, PharmD
[+] Author Affiliations

Read in part before the Society for Adolescent Medicine, San Francisco, Oct 22, 1983.

Reprint requests to Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 (Mr DuRant).


Am J Dis Child. 1985;139(5):489-493. doi:10.1001/archpedi.1985.02140070063035.
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References
Comments

• The efficacy of different regimens of naproxen sodium for relief of dysmenorrhea in female adolescents was compared and the effect of other social/psychologic factors on the response to treatment tested. Following pretesting, 45 female adolescents were randomly assigned in a double-blind fashion to one of five treatment regimens and were followed up after 1, 2, and 3 months of treatment. There was a dose-related response to naproxen sodium therapy, with subjects receiving loading doses of 550 mg reporting better symptom relief than subjects receiving loading doses of 275 mg. During the first month of treatment, adolescents who reported increased life crisis events experienced greater symptom severity following naproxen therapy. Also, adolescents who reported more severe dysmenorrhea symptoms following three months of naproxen therapy had significantly lower self-concepts than adolescents who reported less symptoms following treatment.

(AJDC 1985;139:489-493)

REFERENCES

1 +
Alvin PE, Litt IF:  Current status of the etiology and management of dysmenorrhea in adolescents . Pediatrics 1982;;70:516-525.
2 +
Jay MS, DuRant RH:  The patient with dysmenorrhea . Postgrad Med 1983;;73:103-111.
3 +
Wildholm O, Kantero RL:  Menstrual patterns of adolescent girls according to chronological and gynecological ages . Acta Obstet Gynecol Scand 1971;;50( (suppl 14) ):19-29.
4 +
Dillien CM:  A study of normal and abnormal menstrual functon in the auxiliary territorial service . J Obstet Gynaecol Br Comm 1946;;53: 228-241.
5 +
Klein JR, Litt IF:  Epidemiology of adolescent dysmenorrhea . Pediatrics 1981;;68:661-664.
6 +
Heald FP, Masland RP Jr, Sturgis SH, et al:  Dysmenorrhea in adolescents . Pediatrics 1957;; 20:121-127.
7 +
Marsland DW, Wood M, Fitzhugh M:  Content of family practice . J Fam Pract 1976;;3:37-45.
8 +
Lennane KJ:  Social and medical attitudes towards dysmenorrhea . J Reprod Med 1980;;25 ( (suppl 4) ):202-206.
9 +
Pickles VR, Hall W, Best FA, et al:  Prostaglandins in endometrium and menstrual fluid from normal dysmenorrheic subjects . J Obstet Gynaecol Br Comm 1965;;72:185-192.
10 +
Friedman WF, Molony DA, Kirkpatrick SE:  Prostaglandins: Physiological and clinical correlations . Adv Pediatr 1978;;25:151-204.
11 +
Olley PM, Coceani F:  The prostaglandins . AJDC 1980;;134:688-696.
12 +
Vane JR:  Inhibitors of prostaglandin, prostacyclin and thromboxane synthesis . Adv Prostaglandin Thromboxane Leukotriene Res 1978;;4: 27-44.
13 +
Simon LS, Mills JA:  Nonsteroidal anti-inflammatory drugs . N Engl J Med 1980;;302: 1179-1185.
14 +
Simon LS, Mills JA:  New nonsteroidal anti-inflammatory drugs . N Engl J Med 1980;;302: 1237-1243.
15 +
Lundstrom V:  Treatment of primary dysmenorrhea with prostaglandin synthetase inhibitors: A promising therapeutic alternative . Acta Obstet Gynecol Scand 1978;;57:421-428.
16 +
Schwartz A, Zor U, Lindner HR, et al:  Primary dysmenorrhea: Alleviation by an inhibitor of prostaglandin synthesis and action . Obstet Gynecol 1974;;44:709-712.
17 +
Henzl MR, Massey S, Hanson F, et al:  Primary dysmenorrhea: The therapeutic challenge . J Reprod Med 1980;;25( (suppl 4) ):226-235.
18 +
Wiqvist N, Wilhelmsson L:  The pathophysiology of primary dysmenorrhea . Res Clin Forums 1979;;1:47-53.
19 +
Ferreira SM, Moncadi S, Vane JR:  Indomethacin and aspirin abolish prostaglandin release from the spleen . Nature 1971;;231:237-239.
20 +
Vane JR:  Inhibition of prostaglandin biosynthesis as a mechanism of action of aspirin-like drugs . Nature 1971;;231:232-236.
21 +
Ferreira SM, Vane JR:  New aspects of the mode of action of non-steroid anti-inflammatory drugs . Ann Rev Pharmacol 1974;;14:57-73.
22 +
Flower RJ:  Drugs which inhibit prostaglandin biosynthesis . Pharmacol Rev 1974;; 26:33-67.
23 +
Segre EJ:  Naproxen sodium (Anaprox): Pharmacology, pharmacokinetics and drug interactions . J Reprod Med 1980;;25( (suppl 4) ):222-225.
24 +
Henzl MR, Buttram V, Segre EJ, et al:  The treatment of dysmenorrhea with naproxen sodium: A report of two independent double-blind trials . Am J Obstet Gynecol 1977;;127:818-823.
25 +
Haman GO:  Severe, primary dysmenorrhea treated with naproxen: A prospective double blind cross-over investigation . Prostaglandins 1980;;19:651-657.
26 +
Moos RH:  The development of a menstrual distress questionnaire . Psychosom Med 1968;;30: 853-867.
27 +
Edgren RA, Fermi M: Double-Blind Study of Various Regimens of Naproxen Sodium in Adolescent Patients Suffering From Severe Dysmenorrhea: Dysmenorrhea Protocol 3-6282 . Palo Alto, Calif, Syntex Laboratories Inc, 1979;.
28 +
Coddington RD:  Life events associated with adolescent pregnancies . J Clin Psychiatry 1979;;40:180-185.
29 +
Piers EV, Harris DB:  Age and other correlates of self-concept in children . J Educ Psychol 1964;;55:91-100.
30 +
Chesney MA, Tasto DL:  The development of the menstrual symptom questionnaire . Behav Res Ther 1975;;13:237-244.
31 +
Hall CH, Nie NH: SPSS Update 7-9: New Releases and Facilities for Releases 7-9 . New York, McGraw-Hill Book Co, 1981;, pp 47-77.
32 +
Neter J, Wasserman W: Applied Linear Statistical Models: Regression Analysis of Variance and Experimental Designs . Homewood, Ill, Richard D Irwin Inc, 1974;, pp 271-296, 685-700, 745-793.
33 +
Henzl MR, Ortega-Herrera E, Rodriquez C, et al:  Anaprox in dysmenorrhea: Reduction of pain and intra-uterine pressure . Am J Obstet Gynecol 1979;;135:455-460.
34 +
Klein JR, Litt IF, Rosenberg A, et al:  Effect of aspirin on dysmenorrhea in adolescents . J Pediatr 1981;;98:987-990.
35 +
Stephenson LA, Denney DR, Aberger EW:  Factor structure of the menstrual symptom questionnaire: Relationship to oral contraceptives, neuroticism and life stress . Behav Res Ther 1983;;21:121-135.
36 +
Green K, Samuelsson B:  Quantitative studies on the synthesis in vivo of prostaglandins in the rat: Cold stress induced stimulation of synthesis . Eur J Biochem 1971;;22:391-395.
37 +
Ignatowska-Switalska H, Klonowicz T, Feltynowski T:  The effect of mental stress on prostaglandin F2 in patients with essential hypertension and in healthy subjects . Clin Sci 1979;;57:2755-2775.
38 +
Tigranian RA, Orloff LL, Kalita NF, et al:  Changes in blood levels of several hormones, catecholamines, prostaglandins, electrolytes and CAMP in men during emotional stress . Endocrinol Exp 1980;;14:101-112.
39 +
Hanukoglu I:  Prostaglandins as first mediator of stress . N Engl J Med 1977;;296:1414.

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References

1 +
Alvin PE, Litt IF:  Current status of the etiology and management of dysmenorrhea in adolescents . Pediatrics 1982;;70:516-525.
2 +
Jay MS, DuRant RH:  The patient with dysmenorrhea . Postgrad Med 1983;;73:103-111.
3 +
Wildholm O, Kantero RL:  Menstrual patterns of adolescent girls according to chronological and gynecological ages . Acta Obstet Gynecol Scand 1971;;50( (suppl 14) ):19-29.
4 +
Dillien CM:  A study of normal and abnormal menstrual functon in the auxiliary territorial service . J Obstet Gynaecol Br Comm 1946;;53: 228-241.
5 +
Klein JR, Litt IF:  Epidemiology of adolescent dysmenorrhea . Pediatrics 1981;;68:661-664.
6 +
Heald FP, Masland RP Jr, Sturgis SH, et al:  Dysmenorrhea in adolescents . Pediatrics 1957;; 20:121-127.
7 +
Marsland DW, Wood M, Fitzhugh M:  Content of family practice . J Fam Pract 1976;;3:37-45.
8 +
Lennane KJ:  Social and medical attitudes towards dysmenorrhea . J Reprod Med 1980;;25 ( (suppl 4) ):202-206.
9 +
Pickles VR, Hall W, Best FA, et al:  Prostaglandins in endometrium and menstrual fluid from normal dysmenorrheic subjects . J Obstet Gynaecol Br Comm 1965;;72:185-192.
10 +
Friedman WF, Molony DA, Kirkpatrick SE:  Prostaglandins: Physiological and clinical correlations . Adv Pediatr 1978;;25:151-204.
11 +
Olley PM, Coceani F:  The prostaglandins . AJDC 1980;;134:688-696.
12 +
Vane JR:  Inhibitors of prostaglandin, prostacyclin and thromboxane synthesis . Adv Prostaglandin Thromboxane Leukotriene Res 1978;;4: 27-44.
13 +
Simon LS, Mills JA:  Nonsteroidal anti-inflammatory drugs . N Engl J Med 1980;;302: 1179-1185.
14 +
Simon LS, Mills JA:  New nonsteroidal anti-inflammatory drugs . N Engl J Med 1980;;302: 1237-1243.
15 +
Lundstrom V:  Treatment of primary dysmenorrhea with prostaglandin synthetase inhibitors: A promising therapeutic alternative . Acta Obstet Gynecol Scand 1978;;57:421-428.
16 +
Schwartz A, Zor U, Lindner HR, et al:  Primary dysmenorrhea: Alleviation by an inhibitor of prostaglandin synthesis and action . Obstet Gynecol 1974;;44:709-712.
17 +
Henzl MR, Massey S, Hanson F, et al:  Primary dysmenorrhea: The therapeutic challenge . J Reprod Med 1980;;25( (suppl 4) ):226-235.
18 +
Wiqvist N, Wilhelmsson L:  The pathophysiology of primary dysmenorrhea . Res Clin Forums 1979;;1:47-53.
19 +
Ferreira SM, Moncadi S, Vane JR:  Indomethacin and aspirin abolish prostaglandin release from the spleen . Nature 1971;;231:237-239.
20 +
Vane JR:  Inhibition of prostaglandin biosynthesis as a mechanism of action of aspirin-like drugs . Nature 1971;;231:232-236.
21 +
Ferreira SM, Vane JR:  New aspects of the mode of action of non-steroid anti-inflammatory drugs . Ann Rev Pharmacol 1974;;14:57-73.
22 +
Flower RJ:  Drugs which inhibit prostaglandin biosynthesis . Pharmacol Rev 1974;; 26:33-67.
23 +
Segre EJ:  Naproxen sodium (Anaprox): Pharmacology, pharmacokinetics and drug interactions . J Reprod Med 1980;;25( (suppl 4) ):222-225.
24 +
Henzl MR, Buttram V, Segre EJ, et al:  The treatment of dysmenorrhea with naproxen sodium: A report of two independent double-blind trials . Am J Obstet Gynecol 1977;;127:818-823.
25 +
Haman GO:  Severe, primary dysmenorrhea treated with naproxen: A prospective double blind cross-over investigation . Prostaglandins 1980;;19:651-657.
26 +
Moos RH:  The development of a menstrual distress questionnaire . Psychosom Med 1968;;30: 853-867.
27 +
Edgren RA, Fermi M: Double-Blind Study of Various Regimens of Naproxen Sodium in Adolescent Patients Suffering From Severe Dysmenorrhea: Dysmenorrhea Protocol 3-6282 . Palo Alto, Calif, Syntex Laboratories Inc, 1979;.
28 +
Coddington RD:  Life events associated with adolescent pregnancies . J Clin Psychiatry 1979;;40:180-185.
29 +
Piers EV, Harris DB:  Age and other correlates of self-concept in children . J Educ Psychol 1964;;55:91-100.
30 +
Chesney MA, Tasto DL:  The development of the menstrual symptom questionnaire . Behav Res Ther 1975;;13:237-244.
31 +
Hall CH, Nie NH: SPSS Update 7-9: New Releases and Facilities for Releases 7-9 . New York, McGraw-Hill Book Co, 1981;, pp 47-77.
32 +
Neter J, Wasserman W: Applied Linear Statistical Models: Regression Analysis of Variance and Experimental Designs . Homewood, Ill, Richard D Irwin Inc, 1974;, pp 271-296, 685-700, 745-793.
33 +
Henzl MR, Ortega-Herrera E, Rodriquez C, et al:  Anaprox in dysmenorrhea: Reduction of pain and intra-uterine pressure . Am J Obstet Gynecol 1979;;135:455-460.
34 +
Klein JR, Litt IF, Rosenberg A, et al:  Effect of aspirin on dysmenorrhea in adolescents . J Pediatr 1981;;98:987-990.
35 +
Stephenson LA, Denney DR, Aberger EW:  Factor structure of the menstrual symptom questionnaire: Relationship to oral contraceptives, neuroticism and life stress . Behav Res Ther 1983;;21:121-135.
36 +
Green K, Samuelsson B:  Quantitative studies on the synthesis in vivo of prostaglandins in the rat: Cold stress induced stimulation of synthesis . Eur J Biochem 1971;;22:391-395.
37 +
Ignatowska-Switalska H, Klonowicz T, Feltynowski T:  The effect of mental stress on prostaglandin F2 in patients with essential hypertension and in healthy subjects . Clin Sci 1979;;57:2755-2775.
38 +
Tigranian RA, Orloff LL, Kalita NF, et al:  Changes in blood levels of several hormones, catecholamines, prostaglandins, electrolytes and CAMP in men during emotional stress . Endocrinol Exp 1980;;14:101-112.
39 +
Hanukoglu I:  Prostaglandins as first mediator of stress . N Engl J Med 1977;;296:1414.

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