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Consequences of Candidemia for Pediatric Patients FREE

Ronald B. Turner, MD; Leigh G. Donowitz, MD; J. Owen Hendley, MD
[+] Author Affiliations

Read before the 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas, Oct 26, 1983.

Reprint requests to Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908 (Dr Hendley).


Am J Dis Child. 1985;139(2):178-180. doi:10.1001/archpedi.1985.02140040080032.
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• The hospital records of 45 infants and children with one or more blood cultures positive for Candida species were studied retrospectively in an attempt to define the risk of Candida-related complications. Death of eight of the patients (18%) was related to Candida infection, and five additional patients (11%) had metastatic foci of infection but survived. No characteristics were identified that would predict patients who were at high risk for complications of candidemia. Eleven patients were treated with amphotericin B for longer than a week and were examined for evidence of nephrotoxicity. None had persistent abnormalities of blood urea nitrogen or serum creatinine concentrations develop during treatment; two patients had hypokalemia.

(AJDC 1985;139:178-180)

REFERENCES

Edwards JE, Lehrer RI, Stiehm ER, et al:  Severe candidal infections: Clinical perspective, immune defense mechanisms and current concepts of therapy . Ann Intern Med 1978;;89:91-106.
Link to Article
Myerowitz RL, Pazin GJ, Allen CM:  Disseminated candidiasis: Changes in incidence, underlying diseases and pathology . Am J Clin Pathol 1977;;68:29-38.
Meunier-Carpentier F, Kiehm TE, Armstrong D:  Fungemia in the immunocompromised host: Changing patterns, antigenemia, high mortality . Am J Med 1981;;71:363-370.
Link to Article
Klein JJ, Watanakunakorn C:  Hospital-acquired fungemia: Its natural course and clinical significance . Am J Med 1979;;67:51-58.
Link to Article
Rose HD, Varkey B:  Deep mycotic infection in the hospitalized adult: A study of 123 patients . Medicine 1975;;54:499-507.
Link to Article
Hughes WT:  Systemic candidiasis: A study of 109 fatal cases . Pediatr Infect Dis 1982;;1:11-18.
Link to Article
Keller MA, Sellers BB, Melish ME, et al:  Systemic candidiasis in infants: A case presentation and literature review . AJDC 1977;;131:1260-1263.
Klein JD, Yamauchi T, Horlick SP:  Neonatal candidiasis, meningitis, and arthritis: Observations and a review of the literature . J Pediatr 1972;;81:31-34.
Link to Article
Young RC, Bennett JE, Geelhoed GW, et al:  Fungemia with compromised host resistance: A study of 70 cases . Ann Intern Med 1974;;80: 605-612.
Link to Article
Wenzel RP, Osterman CA, Hunting KJ, et al:  Hospital-acquired infections: I. Surveillance in a university hospital . Am J Epidemiol 1976;;103:251-260.
Haley LD, Callaway CS: Laboratory Methods in Medical Mycology , ed 4. Atlanta, Centers for Disease Control, 1978;.
Meites S: Pediatric Clinical Chemistry: A Survey of Normals, Methods, and Instrumentation With Commentary . Washington, DC, American Association for Clinical Chemistry Inc, 1977;, pp 89-91.
Stonestreet BS, Oh W:  Plasma creatinine levels in low-birth-weight infants during the first three months of life . J Pediatr 1978;;61:788-789.
Cherry JD, Lloyd CA, Quilty JF, et al:  Amphotericin B therapy in children: A review of the literature and a case report . J Pediatr 1969;;75:1063-1069.
Link to Article
Baley JE, Kliegman RM, Fanaroff AA:  Disseminated fungal infections in very low-birth-weight infants: Therapeutic toxicity . Pediatrics 1984;;73:153-157.

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References

Edwards JE, Lehrer RI, Stiehm ER, et al:  Severe candidal infections: Clinical perspective, immune defense mechanisms and current concepts of therapy . Ann Intern Med 1978;;89:91-106.
Link to Article
Myerowitz RL, Pazin GJ, Allen CM:  Disseminated candidiasis: Changes in incidence, underlying diseases and pathology . Am J Clin Pathol 1977;;68:29-38.
Meunier-Carpentier F, Kiehm TE, Armstrong D:  Fungemia in the immunocompromised host: Changing patterns, antigenemia, high mortality . Am J Med 1981;;71:363-370.
Link to Article
Klein JJ, Watanakunakorn C:  Hospital-acquired fungemia: Its natural course and clinical significance . Am J Med 1979;;67:51-58.
Link to Article
Rose HD, Varkey B:  Deep mycotic infection in the hospitalized adult: A study of 123 patients . Medicine 1975;;54:499-507.
Link to Article
Hughes WT:  Systemic candidiasis: A study of 109 fatal cases . Pediatr Infect Dis 1982;;1:11-18.
Link to Article
Keller MA, Sellers BB, Melish ME, et al:  Systemic candidiasis in infants: A case presentation and literature review . AJDC 1977;;131:1260-1263.
Klein JD, Yamauchi T, Horlick SP:  Neonatal candidiasis, meningitis, and arthritis: Observations and a review of the literature . J Pediatr 1972;;81:31-34.
Link to Article
Young RC, Bennett JE, Geelhoed GW, et al:  Fungemia with compromised host resistance: A study of 70 cases . Ann Intern Med 1974;;80: 605-612.
Link to Article
Wenzel RP, Osterman CA, Hunting KJ, et al:  Hospital-acquired infections: I. Surveillance in a university hospital . Am J Epidemiol 1976;;103:251-260.
Haley LD, Callaway CS: Laboratory Methods in Medical Mycology , ed 4. Atlanta, Centers for Disease Control, 1978;.
Meites S: Pediatric Clinical Chemistry: A Survey of Normals, Methods, and Instrumentation With Commentary . Washington, DC, American Association for Clinical Chemistry Inc, 1977;, pp 89-91.
Stonestreet BS, Oh W:  Plasma creatinine levels in low-birth-weight infants during the first three months of life . J Pediatr 1978;;61:788-789.
Cherry JD, Lloyd CA, Quilty JF, et al:  Amphotericin B therapy in children: A review of the literature and a case report . J Pediatr 1969;;75:1063-1069.
Link to Article
Baley JE, Kliegman RM, Fanaroff AA:  Disseminated fungal infections in very low-birth-weight infants: Therapeutic toxicity . Pediatrics 1984;;73:153-157.

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