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Defective Neutrophil Motility

Am J Dis Child. 1985;139(1):10. doi:10.1001/archpedi.1985.02140030012007.
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Sir.—We read with interest the article by Maggiore et al1 entitled "Defective Neutrophil Motility in Children With Chronic Liver Disease."

Since defective neutrophil motility was primarily shown in children with chronic active hepatitis and chronic persistent hepatitis, we would like to note that defective chemotaxis has previously been reported in cirrhotic patients.2 Defective neutrophil chemotaxis has also been shown in cirrhotic children (mean±SD, 51.9±16.2 μm v 73.1±14.1 μm; P<.001) in our department. This finding was correlated with the neutrophil zinc level (0.0083 ± 0.0027 μg/106 cells v 0.0134 ±0.0033 μg/106 cells; P<.001), without any difference in neutrophil random migration. This chemotactic defect was basically corrected when the patients' neutrophils were incubated with control serum samples or zinc (0.05 mL of neutrophil mixture and 1 μg of zinc), but the patients' serum samples in general had an inhibitor effect on control neutrophil chemotaxis (N.A.


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