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Fetal Hydantoin Syndrome Characteristics-Reply

Am J Dis Child. 1984;138(12):1155. doi:10.1001/archpedi.1984.02140500058022.
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In Reply.—Dr Robinow has stated that several of the anomalies related in our report are "defects not previously described as part of the fetal hydantoin syndrome." Unfortunately, this is not the case. The defects of imperforate anus (anal atresia), rib and vertebral anomalies, a single umbilical artery, and dislocation of the hip are specifically mentioned in the two classic textbooks by Smith and Taybi as being part of the fetal hydantoin syndrome.1,2 These defects are also acknowledged in articles cited in the reference list of our report. "Renal malformations," as well as descriptions of numerous other genitourinary abnormalities, are also listed by these and other authors. Since rectoperineal or rectogenital fistulas are classic findings in infants with imperforate anus or anal ectopia, this would be an expected occurrence in such patients. Renal agenesis, while not specifically mentioned previously, would seem to fit logically within the realm of renal


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