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Cell Receptors FREE

Solomon A. Kaplan, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, UCLA Medical Center, Los Angeles, CA 90024 (Dr Kaplan).


Am J Dis Child. 1984;138(12):1140-1146. doi:10.1001/archpedi.1984.02140500046017.
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The scheme of evolution required the specialization of parts or organs of the body to undertake discrete functions, eg, the muscles provide locomotion, the gut digests and absorbs nutrition, and the kidneys maintain a constant chemical internal milieu. This specialization, however, could only proceed if a system of communication developed between organs so that their functions could be integrated to benefit the whole organism. This was achieved in two ways—by the transmission of electrical impulses through the nervous system and the transmission of chemical messages through the circulatory system. This review will discuss some of the features of the latter system.

It is evident that these communicating signals must be precisely controlled, and that the controls themselves must be kept under lock and key. For example, the liver must be ready at all times to guard against the dangers of hypoglycemia by maintaining a store of glycogen and the enzymes

REFERENCES

Robison GA, Butcher RW, Sutherland FW (eds): Cyclic AMP . Academic Press Inc, New York, 1971;, p 107.
Katt KJ, Dufau ML:  The clinical significance of peptide hormone receptors , in Clayton RN (ed): Clinics in Endocrinology and Metabolism . Philadelphia, WB Saunders Co, 1983;, pp XI-XLV.
Vincent A:  Acetylcholine receptors and myasthenia gravis , in Clayton RN (ed): Clinics in Endocrinology and Metabolism . WB Saunders Co, 1983;, pp 57-78.
Kidd A, Okita N, Row VV, et al:  Progress in endocrinology and metabolism: Immunologic aspects of Graves' and Hashimoto's diseases . Metabolism 1980;;29:80-99.
Roth J, Grunfeld C:  Endocrine systems: Mechanisms of disease, target cells and receptors , in Williams RH (ed): Textbook of Endocrinology . Philadelphia, WB Saunders Co, 1981;, pp 15-72.
Kaplan SA:  The insulin receptor . J Pediatr 1984;;104:327-336.
Czech MP, Massague J:  Subunit structure and dynamics of the insulin receptor . Fed Proc 1982;;41:2719-2723.
Melmon KL:  The endocrine function of selected autocoids, catecholamines, acetylcholine, serotonin and histamine , in Williams RH (ed): Textbook of Endocrinology . Philadelphia, WB Saunders Co, 1981;, pp 514-587.
Lefkowitz RJ, Caron MG, Styler GL:  Mechanisms of membrane-receptor regulation: Biochemical, physiological and clinical insights derived from adrenergic receptors . N Engl J Med 1984;;310:1570-1579.
Hertzig JH:  The role of calcium ions in the regulation of myocardial contractility . Triangle 1983;;22:31-46.
Farese RV:  Phospholipids as intermediates in hormone action . Mol Cell Endocrinol 1984;;35:1-4.
Farfel Z, Bourne HR:  Deficient activity of receptor-cyclase coupling protein in platelets with pseudohypoparathyroidism . J Clin Endocrinol Metabol 1980;;51:1202-1204.
Lord JAH, Waterfield AA, Hughes J, et al:  Endogenous opiate peptides: Multiple agonists and receptors . Nature 1977;;267:495-499.
Gorski J, Gannon F:  Current models of steroid hormone action: A critical review . Ann Rev Physiol 1976;;38:425-450.
Baxter JD, Funder JW:  Hormone receptors . N Engl J Med 1979;;301:1149-1161.
Griffin JE, Wilson JD:  The syndromes of androgen resistance . N Engl J Med 1980;;302: 198-209.
Goldstein JL, Brown MS:  The LDL receptor defect in familial hypercholesterolemia: Implications for pathogenesis and therapy . Med Clin North Am 1982;;66:335-362.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Robison GA, Butcher RW, Sutherland FW (eds): Cyclic AMP . Academic Press Inc, New York, 1971;, p 107.
Katt KJ, Dufau ML:  The clinical significance of peptide hormone receptors , in Clayton RN (ed): Clinics in Endocrinology and Metabolism . Philadelphia, WB Saunders Co, 1983;, pp XI-XLV.
Vincent A:  Acetylcholine receptors and myasthenia gravis , in Clayton RN (ed): Clinics in Endocrinology and Metabolism . WB Saunders Co, 1983;, pp 57-78.
Kidd A, Okita N, Row VV, et al:  Progress in endocrinology and metabolism: Immunologic aspects of Graves' and Hashimoto's diseases . Metabolism 1980;;29:80-99.
Roth J, Grunfeld C:  Endocrine systems: Mechanisms of disease, target cells and receptors , in Williams RH (ed): Textbook of Endocrinology . Philadelphia, WB Saunders Co, 1981;, pp 15-72.
Kaplan SA:  The insulin receptor . J Pediatr 1984;;104:327-336.
Czech MP, Massague J:  Subunit structure and dynamics of the insulin receptor . Fed Proc 1982;;41:2719-2723.
Melmon KL:  The endocrine function of selected autocoids, catecholamines, acetylcholine, serotonin and histamine , in Williams RH (ed): Textbook of Endocrinology . Philadelphia, WB Saunders Co, 1981;, pp 514-587.
Lefkowitz RJ, Caron MG, Styler GL:  Mechanisms of membrane-receptor regulation: Biochemical, physiological and clinical insights derived from adrenergic receptors . N Engl J Med 1984;;310:1570-1579.
Hertzig JH:  The role of calcium ions in the regulation of myocardial contractility . Triangle 1983;;22:31-46.
Farese RV:  Phospholipids as intermediates in hormone action . Mol Cell Endocrinol 1984;;35:1-4.
Farfel Z, Bourne HR:  Deficient activity of receptor-cyclase coupling protein in platelets with pseudohypoparathyroidism . J Clin Endocrinol Metabol 1980;;51:1202-1204.
Lord JAH, Waterfield AA, Hughes J, et al:  Endogenous opiate peptides: Multiple agonists and receptors . Nature 1977;;267:495-499.
Gorski J, Gannon F:  Current models of steroid hormone action: A critical review . Ann Rev Physiol 1976;;38:425-450.
Baxter JD, Funder JW:  Hormone receptors . N Engl J Med 1979;;301:1149-1161.
Griffin JE, Wilson JD:  The syndromes of androgen resistance . N Engl J Med 1980;;302: 198-209.
Goldstein JL, Brown MS:  The LDL receptor defect in familial hypercholesterolemia: Implications for pathogenesis and therapy . Med Clin North Am 1982;;66:335-362.

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