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December 1984, Vol 138, No. 12 >
Article | December 1984

Weaver-Smith Syndrome:  A Case Study With Long-term Follow-up FREE

Naomi Amir, MD; Eva Gross-Kieselstein, MD; Harry J. Hirsch, MD; Emeric Lax, MD; Ruth Silverberg-Shalev, MD
[+] Author Affiliations

Reprint requests to Department of Pediatric Neurology, Bikur Cholim Hospital, 3-5 Strauss St, Jerusalem, Israel (Dr Shalev).


Am J Dis Child. 1984;138(12):1113-1117. doi:10.1001/archpedi.1984.02140500019006.
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References
Comments

• We studied a 6-year-old-boy who was followed up from infancy and who had Weaver-Smith syndrome (WSS), a syndrome characterized by excessive growth, dysmorphic facies, psychomotor retardation, and specific radiologic features. The child's height and bone age were far greater than his chronological age and he demonstrated hypothyroidism at the age of 6 years, but had no endocrinologic abnormalities when he was examined at 11 months of age and again at 4 years of age. We compared the clinical and laboratory features of this child with all other reported cases of WSS.

(AJDC 1984;138:1113-1117)

REFERENCES

1 +
Weaver DW, Graham CB, Thomas IT, et al:  A new overgrowth syndrome with accelerated skeletal maturation, unusual facies, and camptodactyly . J Pediatr 1974;;84:547-552.
2 +
Moreno HC, Zachai EH, Kaufman HJ, et al:  Case report 18 . Syndrome Identification 1974;;2: 22-25.
3 +
Gemme G, Bonioli E, Ruffa G, et al:  The Weaver-Smith syndrome . J Pediatr 1980;;97:962-963.
4 +
Majewski F, Ranke M, Kemperdick H, et al:  The Weaver syndrome: A rare type of primordial overgrowth . Eur J Pediatr 1981;;137:277-282.
5 +
Weisswichert PH, Knapp G, Willich E:  Accelerated bone maturation syndrome of the Weaver type . Eur J Pediatr 1981;;137:329-333.
6 +
Hansman CF:  Growth of interorbital distance and skull thickness as observed in roentgenographic measurements . Radiology 1966;;86: 87-96.
7 +
Greulich WW, Pyle JI: Radiographic Atlas of Skeletal Development of the Hand and Wrist . Stanford, Calif, Stanford University Press, 1959;.
8 +
Paul LW, Juhl JH: The Essentials of Roentgen Interpretation . Hagerstown, Md, Harper & Row Publishers Inc, 1972;.
9 +
Hook EB, Reynolds JW:  Cerebral gigantism: Endocrinological and clinical observations of six patients including a congenital giant, concordant monozygotic twins, and a child who achieved adult gigantic size . J Pediatr 1967;;70: 900-914.
10 +
Fitch N:  The syndromes of Marshall and Weaver . J Med Genet 1980;;17:174-178.
11 +
Sotelo-Avila C, Singer DB:  Syndrome of hyperplastic fetal visceromegaly and neonatal hypoglycemia (Beckwith's syndrome): A report of seven cases . Pediatrics 1970;;46:240-250.
12 +
Martin JB:  Neural regulation of growth hormone secretion . N Engl J Med 1973;;288: 1384-1392.
13 +
Smith DW: Recognizable Patterns of Human Malformation . Philadelphia, WB Saunders Co, 1976;, pp 88-96.
14 +
Dodge PR, Holmes SJ, Sotos JF:  Cerebral gigantism . Dev Med Child Neurol 1983;;25:248-251.
15 +
Nelson WE, Vaughan VC III, McKay RJ (eds): Textbook of Pediatrics , ed 9. Philadelphia, WB Saunders Co, 1971;, p 41.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Weaver DW, Graham CB, Thomas IT, et al:  A new overgrowth syndrome with accelerated skeletal maturation, unusual facies, and camptodactyly . J Pediatr 1974;;84:547-552.
2 +
Moreno HC, Zachai EH, Kaufman HJ, et al:  Case report 18 . Syndrome Identification 1974;;2: 22-25.
3 +
Gemme G, Bonioli E, Ruffa G, et al:  The Weaver-Smith syndrome . J Pediatr 1980;;97:962-963.
4 +
Majewski F, Ranke M, Kemperdick H, et al:  The Weaver syndrome: A rare type of primordial overgrowth . Eur J Pediatr 1981;;137:277-282.
5 +
Weisswichert PH, Knapp G, Willich E:  Accelerated bone maturation syndrome of the Weaver type . Eur J Pediatr 1981;;137:329-333.
6 +
Hansman CF:  Growth of interorbital distance and skull thickness as observed in roentgenographic measurements . Radiology 1966;;86: 87-96.
7 +
Greulich WW, Pyle JI: Radiographic Atlas of Skeletal Development of the Hand and Wrist . Stanford, Calif, Stanford University Press, 1959;.
8 +
Paul LW, Juhl JH: The Essentials of Roentgen Interpretation . Hagerstown, Md, Harper & Row Publishers Inc, 1972;.
9 +
Hook EB, Reynolds JW:  Cerebral gigantism: Endocrinological and clinical observations of six patients including a congenital giant, concordant monozygotic twins, and a child who achieved adult gigantic size . J Pediatr 1967;;70: 900-914.
10 +
Fitch N:  The syndromes of Marshall and Weaver . J Med Genet 1980;;17:174-178.
11 +
Sotelo-Avila C, Singer DB:  Syndrome of hyperplastic fetal visceromegaly and neonatal hypoglycemia (Beckwith's syndrome): A report of seven cases . Pediatrics 1970;;46:240-250.
12 +
Martin JB:  Neural regulation of growth hormone secretion . N Engl J Med 1973;;288: 1384-1392.
13 +
Smith DW: Recognizable Patterns of Human Malformation . Philadelphia, WB Saunders Co, 1976;, pp 88-96.
14 +
Dodge PR, Holmes SJ, Sotos JF:  Cerebral gigantism . Dev Med Child Neurol 1983;;25:248-251.
15 +
Nelson WE, Vaughan VC III, McKay RJ (eds): Textbook of Pediatrics , ed 9. Philadelphia, WB Saunders Co, 1971;, p 41.

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