• A prospective study investigated poisonings that occur away from home. During the study period, 13% of all poisonings involving children aged 5 years or younger occurred away from home. Drugs accounted for most of these poisonings in both study and control (cases randomly selected from poisoning that occurred at home) groups. The potential toxicity of products involved in the study group was significantly greater than that in controls. Prescription drug poisonings, which occurred with similar frequency in study and control groups, were more potentially toxic in the former. The availability of ipecac syrup was significantly less in the study group. Grandparents' homes, the most common location in the study group, also had the lowest availability of ipecac. Poisonings away from home are frequent, potentially dangerous, and these environments are less adequately prepared to handle such exposures.