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October 1984, Vol 138, No. 10 >
Article | October 1984

Purpura Fulminans Following Late-Onset Group B β-Hemolytic Streptococcal Sepsis FREE

Scott H. Isaacman, MD; William M. Heroman, MD; Alton L. Lightsey, MD
[+] Author Affiliations

The opinions or assertions contained herein are those of the authors and are not to be construed as official or as necessarily reflecting the views of the Department of the Navy or the naval service at large.

Reprint requests to Clinical Investigation Department, Naval Hospital, San Diego, CA 92134 (Dr Isaacman).


Am J Dis Child. 1984;138(10):915-916. doi:10.1001/archpedi.1984.02140480017006.
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• A 16-day-old male infant initially was in septic shock. Following intensive resuscitation, thrombohemorrhagic lesions developed over his extremities, except for the limb with an arterial line maintained by a continuous heparin sodium infusion. Blood and CSF cultures yielded group B β-hemolytic streptococci. Results of laboratory studies and clinical appearance supported the diagnosis of purpura fulminans (PF). Systemic heparinization was therefore started, and subsequently his condition improved. Because of the distinct difference in limb sparing, we concluded heparin has a beneficial effect on the evolution of PF.

(AJDC 1984;138:915-916)

REFERENCES

1 +
Hjort PF, Rappaport SI, Jorgensen L:  Purpura fulminans: Report of a case successfully treated with heparin and hydrocortisone: Review of 50 cases from literature . Scand J Haematol 1964;;1:169-192.
2 +
Spicer TE, Rau JM:  Purpura fulminans . Am J Med 1976;;61:566-571.
3 +
Leavell UW, Nunnelly P, Mersack, IP:  Cutaneous changes in a case of purpura fulminans following pneumococcal pneumonia . J Ky Med Assoc 1972;;70:853-856.
4 +
Dudgeon DL, Kellogg DR, Gilchrist GS, et al:  Purpura fulminans . Arch Surg 1971;;103: 351-358.
5 +
Chu OZJ, Blaisdell FW:  Purpura fulminans . Am J Surg 1982;;143:356-362.
6 +
Waddell WB, Salteman HA, Fuson RL, et al:  Purpura gangrenosa treated with hyperbaric oxygen . JAMA 1965;;191:971-974.
7 +
Kuzembo JA, Loder RE:  Purpura fulminans treated with hyperbaric oxygen . Br Med J 1970;; 4:157.
8 +
Patterson JH, Pierce RB, Amerson RJ, et al:  Dextran therapy of purpura fulminans . N Engl J Med 1965;;273:734-737.
9 +
Littel JR:  Purpura fulminans treated successfully with anticoagulation: Report of a case . JAMA 1959;;169:36-40.
10 +
Allen DM:  Heparin therapy of purpura fulminans . Pediatrics 1966;;38:211-214.
11 +
Antley RM, McMillan CW:  Sequential coagulation studies in purpura fulminans . N Engl J Med 1967;;276:1287-1290.
12 +
Lipinski B, Jeljaszeqicz J:  A hypothesis for the pathogenesis of the generalized Shwartzman reaction . J Infect Dis 1969;;120:160-168.

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References

1 +
Hjort PF, Rappaport SI, Jorgensen L:  Purpura fulminans: Report of a case successfully treated with heparin and hydrocortisone: Review of 50 cases from literature . Scand J Haematol 1964;;1:169-192.
2 +
Spicer TE, Rau JM:  Purpura fulminans . Am J Med 1976;;61:566-571.
3 +
Leavell UW, Nunnelly P, Mersack, IP:  Cutaneous changes in a case of purpura fulminans following pneumococcal pneumonia . J Ky Med Assoc 1972;;70:853-856.
4 +
Dudgeon DL, Kellogg DR, Gilchrist GS, et al:  Purpura fulminans . Arch Surg 1971;;103: 351-358.
5 +
Chu OZJ, Blaisdell FW:  Purpura fulminans . Am J Surg 1982;;143:356-362.
6 +
Waddell WB, Salteman HA, Fuson RL, et al:  Purpura gangrenosa treated with hyperbaric oxygen . JAMA 1965;;191:971-974.
7 +
Kuzembo JA, Loder RE:  Purpura fulminans treated with hyperbaric oxygen . Br Med J 1970;; 4:157.
8 +
Patterson JH, Pierce RB, Amerson RJ, et al:  Dextran therapy of purpura fulminans . N Engl J Med 1965;;273:734-737.
9 +
Littel JR:  Purpura fulminans treated successfully with anticoagulation: Report of a case . JAMA 1959;;169:36-40.
10 +
Allen DM:  Heparin therapy of purpura fulminans . Pediatrics 1966;;38:211-214.
11 +
Antley RM, McMillan CW:  Sequential coagulation studies in purpura fulminans . N Engl J Med 1967;;276:1287-1290.
12 +
Lipinski B, Jeljaszeqicz J:  A hypothesis for the pathogenesis of the generalized Shwartzman reaction . J Infect Dis 1969;;120:160-168.

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