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August 1984, Vol 138, No. 8 >
Article | August 1984

Severe Hepatitis B Virus—Negative Chronic Hepatitis Responsive to Steroids in a Child With Common Variable Hypogammaglobulinemia FREE

GLUSEPPE MAGGIORE, MD; COSTANTINO DE GIACOMO, MD; NICOLA RASCIO, MD; GIANLUIGI MARSEGLIA, MD; MARZIA DUSE, MD; ALBERTO G. UGAZIO, MD
Am J Dis Child. 1984;138(8):796. doi:10.1001/archpedi.1984.02140460086033.
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Sir.—We read with interest the report by Hauser et al1 on 30 children with common variable hypogammaglobulinemia (CVHG). One of them died of chronic active hepatitis (CAH) due to hepatitis B virus (HBV) infection.

Liver disease is uncommon in children with primary hypogammaglobulinemia,2 but CAH related to HBV infection already has been described in young adults.3 We report the case of a young boy with CVHG who manifested an HBV-negative hepatitis and was successfully treated with steroids.

Report of a Case.—A 9-year-old boy had been apparently well until 3 years of age, when the onset of various bacterial infections (pneumonia with pleural effusion, acute otitis media, and pericarditis) together with the finding of panhypogammaglobulinemia and normal peripheral blood B lymphocytes led to the diagnosis of CVHG. He was then treated with intramuscular γ-globulin replacement, periodic cycles of antibiotics, and chest physiotherapy. From the age of

REFERENCES

1 +
Hauser C, Virelizier J-L, Buriot D, et al:  Common variable hypogammaglobulinemia in children . AJDC 1983;;137:833-837.
2 +
Asherson GL, Webster ADB: Diagnosis and Treatment of Immunodeficiency Disease . Oxford, England, Blackwell Scientific Publishers, 1980;, vol 4, p 74.
3 +
Surrenti C, Casini MC, Romagnani S, et al:  Variable immunodeficiency syndrome and active chronic hepatitis: Report of two cases . Ital J Gastroenterol 1978;;10:107-111.
4 +
Odièvre M, Maggiore G, Homberg JC, et al:  Seroimmunological classification of chronic hepatitis in 57 children . Hepatology 1983;;3:407-409.
5 +
Scotto J, Hadchouel M, Hery C, et al:  Hepatitis B virus DNA in children's liver disease: Detection by blot hybridization in liver and serum . Gut 1983;;24:618-624.
6 +
Solley GO, Dickson ER, Gleich GJ, et al:  Chronic active liver disease with common variable hypogammaglobulinemia . Mayo Clin Proc 1979;;54:127-130.
7 +
Locasciulli A, Alberti A, Barbieri R, et al:  Evidence of non-A, non-B hepatitis in children with acute leukemia and chronic liver disease . AJDC 1983;;137:354-356.
8 +
Maggiore G, Bernard O, Hadchouel M, et al: Treatment of autoimmune chronic active hepatitis in childhood. J Pediatr, in press.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Hauser C, Virelizier J-L, Buriot D, et al:  Common variable hypogammaglobulinemia in children . AJDC 1983;;137:833-837.
2 +
Asherson GL, Webster ADB: Diagnosis and Treatment of Immunodeficiency Disease . Oxford, England, Blackwell Scientific Publishers, 1980;, vol 4, p 74.
3 +
Surrenti C, Casini MC, Romagnani S, et al:  Variable immunodeficiency syndrome and active chronic hepatitis: Report of two cases . Ital J Gastroenterol 1978;;10:107-111.
4 +
Odièvre M, Maggiore G, Homberg JC, et al:  Seroimmunological classification of chronic hepatitis in 57 children . Hepatology 1983;;3:407-409.
5 +
Scotto J, Hadchouel M, Hery C, et al:  Hepatitis B virus DNA in children's liver disease: Detection by blot hybridization in liver and serum . Gut 1983;;24:618-624.
6 +
Solley GO, Dickson ER, Gleich GJ, et al:  Chronic active liver disease with common variable hypogammaglobulinemia . Mayo Clin Proc 1979;;54:127-130.
7 +
Locasciulli A, Alberti A, Barbieri R, et al:  Evidence of non-A, non-B hepatitis in children with acute leukemia and chronic liver disease . AJDC 1983;;137:354-356.
8 +
Maggiore G, Bernard O, Hadchouel M, et al: Treatment of autoimmune chronic active hepatitis in childhood. J Pediatr, in press.

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