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Late-Onset Group B Streptococcal Disease After Peripartum Ampicillin Prophylaxis

PAULA J. AUCOIN, MD; SARAH H. CHEESEMAN, MD
Am J Dis Child. 1984;138(8):795. doi:10.1001/archpedi.1984.02140460085031.
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Sir.—We report a recent episode of late-onset group B streptococcal (GBS) sepsis in a child following vigorous attempts at prophylaxis for known maternal vaginal colonization.

Report of a Case.—The neonate was the normal 3,000-g product of a 41-week pregnancy with vaginal delivery 2½ hours after the spontaneous rupture of the membranes. At seven months' gestation GBS had been isolated from the mother's cervix and treated with seven days of oral ampicillin sodium, 2 g/day. Reculture in the ninth month of pregnancy was negative for GBS. Shortly prior to delivery, the mother was given 1 g of ampicillin sodium intravenously. Postpartum cultures of the cervix and placenta were negative for Streptococcus. At birth, the neonate was meconium-stained, and the urine, ear canal, blood, spinal fluid, and gastric contents were cultured. Ampicillin and gentamicin sulfate administration was begun empirically. The neonate exhibited no signs of sepsis in the first 48

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