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May 1984, Vol 138, No. 5 >
Article | May 1984

Unusual Appearance of Crohn's Disease FREE

William M. Ramsdell, MD; Robert J. Shulman, MD; Carlos H. Lifschitz, MD
[+] Author Affiliations

Read before the Society for Pediatric Dermatology, Aspen, Colo, July 13, 1982.

Reprint requests to Section of Nutrition and Gastroenterology, Texas Children's Hospital, 6621 Fannin St, Houston, TX 77030 (Dr Shulman).


Am J Dis Child. 1984;138(5):500-501. doi:10.1001/archpedi.1984.02140430076020.
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• The association of perianal fistulas and Crohn's disease is well recognized. The appearance of lesions distant from the anal area is, however, uncommon. A young girl appeared with a history of weight loss and extensive mucocutaneous ulcerations. Diarrhea subsequently developed. Colonoscopy revealed friability, edema, and ulcerations. A crypt abscess was found in colonic biopsy specimens. Treatment with prednisolone acetate and sulfasalazine resulted in prompt improvement. A skin biopsy done initially and repeated colon biopsy three months later demonstrated granulomas, consistent with Crohn's disease. The literature regarding skin lesions in association with Crohn's disease is reviewed and the importance of recognizing the cutaneous manifestations of Crohn's disease is emphasized.

(AJDC 1984;138:500-501)

REFERENCES

1 +
Crohn BB, Ginzburg L, Oppenheimer GD:  Regional ileitis . JAMA 1932;;99:1323-1329.
2 +
Schmitz-Moormann P:  Pathologische Anatomie und Histologie des Morbus Crohn . Monatsschr Kinderheilkd 1981;;129:127-132.
3 +
Ament ME:  Inflammatory disease of the colon: Ulcerative colitis and Crohn's colitis . J Pediatr 1975;;86:322-334.
4 +
Silverman A, Roy CC: Inflammatory Bowel Diseases in Pediatric Clinical Gastroenterology . St Louis, CV Mosby Co, 1983;.
5 +
Rankin GB, Watts HD, Melnyk CS, et al:  National cooperative Crohn's disease study: Extraintestinal manifestations and perianal complications . Gastroenterology 1979;;77:914-920.
6 +
Lockhart-Mummery HE, Morson BC:  Crohn's disease of the large intestine . Gut 1964;;5:493-509.
7 +
Krieg H, Brunner H, Gamstatter G, et al:  Anale and perianale Komplikationen beim Morbus Crohn . MMW 1977;;119:193-196.
8 +
Burgdorf W:  Cutaneous manifestations of Crohn's disease . J Am Acad Dermatol 1981;;5: 689-695.
9 +
McCollum DI, Kinmont PDC:  Dermatological manifestations of Crohn's disease . Br J Dermatol 1968;;80:1-8.
10 +
Parks AG, Morson BC, Pegum JS:  Crohn's disease with cutaneous involvement . Proc R Soc Med 1965;;58:241-242.
11 +
Mountain JC:  Cutaneous ulceration in Crohn's disease . Gut 1970;;11:18-26.
12 +
Lilbermann TR, Greene JF Jr:  Transient subcutaneous granulomatosis of the upper extremities in Crohn's disease . Am J Gastroenterol 1979;;72:89-90.
13 +
Lindsley CB, Schaller JG:  Arthritis associated with inflammatory bowel disease in children . J Pediatr 1974;;84:16-20.
14 +
Basu MK, Asquith P:  Oral manifestations of inflammatory bowel disease . Clin Gastroenterol 1980;;9:307-321.
15 +
Kasahara Y, Tanaka S, Nishino M, et al:  Intestinal involvement in Behçet's disease . Dis Colon Rectum 1981;;24:103-106.
16 +
James DG:  Behçet's syndrome . N Engl J Med 1979;;301:431-432.

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References

1 +
Crohn BB, Ginzburg L, Oppenheimer GD:  Regional ileitis . JAMA 1932;;99:1323-1329.
2 +
Schmitz-Moormann P:  Pathologische Anatomie und Histologie des Morbus Crohn . Monatsschr Kinderheilkd 1981;;129:127-132.
3 +
Ament ME:  Inflammatory disease of the colon: Ulcerative colitis and Crohn's colitis . J Pediatr 1975;;86:322-334.
4 +
Silverman A, Roy CC: Inflammatory Bowel Diseases in Pediatric Clinical Gastroenterology . St Louis, CV Mosby Co, 1983;.
5 +
Rankin GB, Watts HD, Melnyk CS, et al:  National cooperative Crohn's disease study: Extraintestinal manifestations and perianal complications . Gastroenterology 1979;;77:914-920.
6 +
Lockhart-Mummery HE, Morson BC:  Crohn's disease of the large intestine . Gut 1964;;5:493-509.
7 +
Krieg H, Brunner H, Gamstatter G, et al:  Anale and perianale Komplikationen beim Morbus Crohn . MMW 1977;;119:193-196.
8 +
Burgdorf W:  Cutaneous manifestations of Crohn's disease . J Am Acad Dermatol 1981;;5: 689-695.
9 +
McCollum DI, Kinmont PDC:  Dermatological manifestations of Crohn's disease . Br J Dermatol 1968;;80:1-8.
10 +
Parks AG, Morson BC, Pegum JS:  Crohn's disease with cutaneous involvement . Proc R Soc Med 1965;;58:241-242.
11 +
Mountain JC:  Cutaneous ulceration in Crohn's disease . Gut 1970;;11:18-26.
12 +
Lilbermann TR, Greene JF Jr:  Transient subcutaneous granulomatosis of the upper extremities in Crohn's disease . Am J Gastroenterol 1979;;72:89-90.
13 +
Lindsley CB, Schaller JG:  Arthritis associated with inflammatory bowel disease in children . J Pediatr 1974;;84:16-20.
14 +
Basu MK, Asquith P:  Oral manifestations of inflammatory bowel disease . Clin Gastroenterol 1980;;9:307-321.
15 +
Kasahara Y, Tanaka S, Nishino M, et al:  Intestinal involvement in Behçet's disease . Dis Colon Rectum 1981;;24:103-106.
16 +
James DG:  Behçet's syndrome . N Engl J Med 1979;;301:431-432.

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