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Aminophylline Reduces Cerebral Blood Flow Velocity in Low-Birth-Weight Infants

Ted S. Rosenkrantz, MD; William Oh, MD
Am J Dis Child. 1984;138(5):489-491. doi:10.1001/archpedi.1984.02140430065017.
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• Cerebral blood flow decreases substantially in the adult after a single bolus injection of aminophylline. To determine if the cerebral circulation of the low-birth-weight infant behaves in a similar manner, we measured cerebral blood flow velocity (CBFV) in the anterior cerebral arteries of nine infants treated with an intravenous bolus dose of 5 mg/kg of body weight of aminophylline. A reduction in CBFV of 21% and 17% was observed at 60 and 120 minutes following the aminophylline administration. There was a concurrent substantial reduction in Pco2 from 45±7 to 39±7 mm Hg before and 120 minutes after the aminophylline administration, respectively. The reduction in CBFV may be the result of a reduction in Pco2 resulting from aminophylline treatment.

(AJDC 1984;138:489-491)

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