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May 1984, Vol 138, No. 5 >
Article | May 1984

Cardiac Complications in Juvenile Hyperthyroidism FREE

Anita Cavallo, MD; Cynthia J. Joseph, MD; Alfonso Casta, MD
[+] Author Affiliations

Reprint requests to Division of Endocrinology, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77550 (Dr Cavallo).


Am J Dis Child. 1984;138(5):479-482. doi:10.1001/archpedi.1984.02140430055014.
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• During a retrospective study, we discovered unusual cardiac manifestations in seven of 21 hyperthyroid patients. Three patients had a transient apical systolic murmur, one had persistent cardiomegaly, and the remaining three had persistent apical systolic murmurs and cardiomegaly; mitral regurgitation and congestive heart failure developed in two of these three patients. Severe, persistent cardiac complications occurred only in patients who had prolonged hyperthyroidism caused by poor compliance with antithyroid drug treatment.

(AJDC 1984;138:479-482)

REFERENCES

1 +
Van Wyk JJ, Grumbach MM, Shepard TH, et al:  The treatment of hyperthyroidism in childhood with thiouracil drugs . Pediatrics 1956;;17: 221-229.
2 +
Vaidya VA, Bongiovanni AM, Parks JS, et al:  Twenty-two years' experience in the medical management of juvenile thyrotoxicosis . Pediatrics 1974;;54:565-570.
3 +
Barnes HV, Blizzard RM:  Antithyroid drug therapy for toxic diffuse goiter (Graves disease): Thirty years' experience in children and adolescents . J Pediatr 1977;;91:313-320.
4 +
McCormick RV:  Periarteritis occurring during propylthiouracil therapy . JAMA 1950;;144: 1453-1454.
5 +
Lerman J, Means JH:  Cardiovascular symptomatology in exophthalmic goiter . Am Heart J 1932;;8:55-65.
6 +
Friedberg CK:  The heart in hyperthyroidism , in Friedberg CK (ed): The Heart . Philadelphia, WB Saunders Co, 1966;, pp 1609-1628.
7 +
Likoff WB, Levine SA:  Thyrotoxicosis as the sole cause of heart failure . Am J Med Sci 1943;;206:425-439.
8 +
Sandler G, Wilson GM:  The nature and prognosis of heart disease in thyrotoxicosis: A review of 150 patients treated with 131I . Q J Med 1959;;28:347-369.
9 +
Graettinger JS, Muenster JJ, Selverstone LA, et al:  A correlation of clinical and hemodynamic studies in patients with hyperthyroidism with and without congestive heart failure . J Clin Invest 1959;;38:1316-1327.
10 +
Pilapil VR, Watson DG:  Electrocardiogram in hyperthyroid children . Am J Dis Child 1970;;119:245-248.
11 +
Reynolds JL, Woody HB:  Thyrotoxic mitral regurgitation: A probable form of intrinsic papillary muscle dysfunction . Am J Dis Child 1971;;122:544-548.
12 +
Lester LA, Sodt PC, Rich BH, et al:  Cardiac abnormalities in children with hyperthyroidism . Pediatr Cardiol 1982;;2:215-223.
13 +
Summers VK, Surtees SJ:  Thyrotoxicosis and heart disease . Acta Med Scand 1961;;169: 661-671.
14 +
Scotti TM:  Heart: Endocrine disturbances—hyperthyroidism , in Anderson WAD, Kissane JM (eds): Pathology . St Louis, CV Mosby Co, 1977;, vol 1, p 750.
15 +
Skelton CL, Sonneblick EH:  Heterogeneity of contractile function in cardiac hypertrophy . Circ Res 1974;;35( (suppl) ):83-96.
16 +
Cohen J:  Role of endocrine factors in the pathogenesis of cardiac hypertrophy . Circ Res 1974;;35( (suppl) ):49-57.
17 +
Shafer RB, Bianco JA:  Assessment of cardiac reserve in patients with hyperthyroidism . Chest 1980;;78:269-273.
18 +
Forfar JC, Muir AL, Sawers SA, et al:  Abnormal left ventricular function in hyperthyroidism: Evidence for a possible reversible cardiomyopathy . N Engl J Med 1982;;307:1165-1170.
19 +
Skelton CL:  The heart and hyperthyroidism . N Engl J Med 1982;;307:1206-1208.
20 +
Piatnek-Leunissen D, Olson RE:  Cardiac failure in the dog as a consequence of exogenous hyperthyroidism . Circ Res 1967;;20:242-252.
21 +
Buckingham BA, Costin G, Roe TF, et al:  Hyperthyroidism in children: A reevaluation of treatment . Am J Dis Child 1981;;135:112-117.

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References

1 +
Van Wyk JJ, Grumbach MM, Shepard TH, et al:  The treatment of hyperthyroidism in childhood with thiouracil drugs . Pediatrics 1956;;17: 221-229.
2 +
Vaidya VA, Bongiovanni AM, Parks JS, et al:  Twenty-two years' experience in the medical management of juvenile thyrotoxicosis . Pediatrics 1974;;54:565-570.
3 +
Barnes HV, Blizzard RM:  Antithyroid drug therapy for toxic diffuse goiter (Graves disease): Thirty years' experience in children and adolescents . J Pediatr 1977;;91:313-320.
4 +
McCormick RV:  Periarteritis occurring during propylthiouracil therapy . JAMA 1950;;144: 1453-1454.
5 +
Lerman J, Means JH:  Cardiovascular symptomatology in exophthalmic goiter . Am Heart J 1932;;8:55-65.
6 +
Friedberg CK:  The heart in hyperthyroidism , in Friedberg CK (ed): The Heart . Philadelphia, WB Saunders Co, 1966;, pp 1609-1628.
7 +
Likoff WB, Levine SA:  Thyrotoxicosis as the sole cause of heart failure . Am J Med Sci 1943;;206:425-439.
8 +
Sandler G, Wilson GM:  The nature and prognosis of heart disease in thyrotoxicosis: A review of 150 patients treated with 131I . Q J Med 1959;;28:347-369.
9 +
Graettinger JS, Muenster JJ, Selverstone LA, et al:  A correlation of clinical and hemodynamic studies in patients with hyperthyroidism with and without congestive heart failure . J Clin Invest 1959;;38:1316-1327.
10 +
Pilapil VR, Watson DG:  Electrocardiogram in hyperthyroid children . Am J Dis Child 1970;;119:245-248.
11 +
Reynolds JL, Woody HB:  Thyrotoxic mitral regurgitation: A probable form of intrinsic papillary muscle dysfunction . Am J Dis Child 1971;;122:544-548.
12 +
Lester LA, Sodt PC, Rich BH, et al:  Cardiac abnormalities in children with hyperthyroidism . Pediatr Cardiol 1982;;2:215-223.
13 +
Summers VK, Surtees SJ:  Thyrotoxicosis and heart disease . Acta Med Scand 1961;;169: 661-671.
14 +
Scotti TM:  Heart: Endocrine disturbances—hyperthyroidism , in Anderson WAD, Kissane JM (eds): Pathology . St Louis, CV Mosby Co, 1977;, vol 1, p 750.
15 +
Skelton CL, Sonneblick EH:  Heterogeneity of contractile function in cardiac hypertrophy . Circ Res 1974;;35( (suppl) ):83-96.
16 +
Cohen J:  Role of endocrine factors in the pathogenesis of cardiac hypertrophy . Circ Res 1974;;35( (suppl) ):49-57.
17 +
Shafer RB, Bianco JA:  Assessment of cardiac reserve in patients with hyperthyroidism . Chest 1980;;78:269-273.
18 +
Forfar JC, Muir AL, Sawers SA, et al:  Abnormal left ventricular function in hyperthyroidism: Evidence for a possible reversible cardiomyopathy . N Engl J Med 1982;;307:1165-1170.
19 +
Skelton CL:  The heart and hyperthyroidism . N Engl J Med 1982;;307:1206-1208.
20 +
Piatnek-Leunissen D, Olson RE:  Cardiac failure in the dog as a consequence of exogenous hyperthyroidism . Circ Res 1967;;20:242-252.
21 +
Buckingham BA, Costin G, Roe TF, et al:  Hyperthyroidism in children: A reevaluation of treatment . Am J Dis Child 1981;;135:112-117.

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