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April 1984, Vol 138, No. 4 >
Article | April 1984

Measles Vaccine and Age at Immunization FREE

ALLAN S. CUNNINGHAM, MD
Am J Dis Child. 1984;138(4):412. doi:10.1001/archpedi.1984.02140420078029.
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Sir.—As recommendations for the measles, mumps, and rubella (MMR) virus vaccine seesaw between 12 and 15 months of age, Faust and Thompson's article1 prompts the following suggestion: If a rigid lower limit of age must be set for MMR vaccine, let it be 11 months (335 days). Antibody titers change little for immunizations given at 11 months of age or thereafter. Wilkins and Wehrle2 found the following percentages of children with hemagglutination inhibition titers of 1:8 or greater, according to age at immunization: 9 months, 72%; 10 months, 84.6%; 11 months, 95.2%; 12 months, 95.4%; 13 months, 96%; 14 months, 95.2%; 15 months, 92.9%; 16 months, 100%; and 17 months and older, 93.2%.

Differences in measles attack rates, according to age at immunization, are negligible so long as the MMR vaccine is given at or after 11 months of age. Marks et al3 reported the only

REFERENCES

1 +
Faust HS, Thompson FE:  Age at and time since vaccination during a measles outbreak in a rural community . AJDC 1983;;137:977-980.
2 +
Wilkins J, Wehrle PF:  Additional evidence against measles vaccine administration to infants less than 12 months of age: Altered immune response following active/passive immunization . J Pediatr 1979;;94:865-869.
3 +
Marks JS, Halpin TJ, Orenstein WA:  Measles vaccine efficacy in children previously vaccinated at 12 months of age . Pediatrics 1978;;62: 955-960.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Faust HS, Thompson FE:  Age at and time since vaccination during a measles outbreak in a rural community . AJDC 1983;;137:977-980.
2 +
Wilkins J, Wehrle PF:  Additional evidence against measles vaccine administration to infants less than 12 months of age: Altered immune response following active/passive immunization . J Pediatr 1979;;94:865-869.
3 +
Marks JS, Halpin TJ, Orenstein WA:  Measles vaccine efficacy in children previously vaccinated at 12 months of age . Pediatrics 1978;;62: 955-960.

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