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Polymicrobial Bacteremia in Pediatric Patients FREE

George T. Frommell, MD; James K. Todd, MD
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Am J Dis Child. 1984;138(3):266-269. doi:10.1001/archpedi.1984.02140410044014.
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• Of 1,352 positive pediatric blood cultures during a 3.6-year period, two or more microorganisms grew from 72 cultures (5.3%), representing 60 patients. Based on predefined operational criteria for clinical interpretation of blood cultures, these cases were retrospectively classified as polymicrobial bacteremia (each organism, ie, a pathogen, 30%), mixed bacteremia/contaminant (20%), or multiple contaminants (50%). Considered individually, gram-positive organisms were isolated more frequently but were more often judged to be contaminants than the less common gram-negative organisms, which were more often thought to be true pathogens. Although one child did have a combined Streptococcus pneumoniae/Hemophilus influenzae bacteremia, these more common pediatric pathogens were underrepresented in those patients with polymicrobial bacteremia, from whom Enterobacterlaceae, streptococci, staphylococci, and anaerobes were more commonly Isolated. Hospitalization for a predisposing Illness and/or a focus of Infection occurred In 88% of the children with confirmed polymicrobial bacteremia.

(AJDC 1984;138:266-269)

REFERENCES

Kanof A, Kramer B:  Multiple invasion of the bloodstream . J Lab Clin Med 1941;;27:173-180.
Hochstein HD, Kirklan WR, Young VM:  Recovery of more than one organism in septicemias . N Engl J Med 1965;;273:468-474.
Bodey GP, Nies BA, Freireich EJ:  Multiple organism septicemia in acute leukemia . Arch Intern Med 1965;;116:267-272.
DuPont HL, Spink WW:  Infections due to gram-negative organisms: An analysis of 860 patients with bacteremia at the University of Minnesota Medical Center, 1958, 1966 . Medicine 1969;;48:307-332.
Hermans PE, Washington JA II:  Polymicrobial bacteremia . Ann Intern Med 1970;;73:387-392.
Monif GRG, Baer H:  Polymicrobial bacteremia in obstetric patients . Obstet Gynecol 1976;;48:167-169.
Kiani D, Quinn EL, Burch KH, et al:  The increasing importance of polymicrobial bacteremia . JAMA 1979;;242:1044-1047.
Mackowaik PA, Browne RH, Southern PM Jr, et al:  Polymicrobial sepsis: An analysis of 184 cases using log linear models . Am J Med Sci 1980;;280:73-80.
Todd JK, Roe MH:  Rapid detection of bacteremia by an early subculture technic . Am J Clin Pathol 1975;;64:694-699.
Lennette E, Spaulding E, Truant J: Manual of Clinical Microbiology . Washington, DC, American Society of Microbiology, 1974;.
Winchester PD, Todd JK, Roe MH:  Bacteremia in hospitalized children . AJDC 1977;; 131:753-758.
Pichichero ME, Todd JK:  Detection of neonatal bacteremia . J Pediatr 1979;;94:958-960.
Grajwer LA, Mukhopadhyay D, Grossman BJ:  Chronic polymicrobial bacteremia . Clin Pediatr 1976;;14:280-283.
Rosenfeld RG, Jameson S:  Polymicrobial bacteremia associated with pharyngotonsillitis . J Pediatr 1978;;93:251-252.
Jarvis WR, Highsmith AK, Allen JR, et al:  Polymicrobial bacteremia associated with lipid emulsion in a neonatal intensive care unit . Pediatr Infect Dis 1983;;2:203-208.
Peter G, Lloyd-Still JD, Lovejoy FH:  Local infection and bacteremia from Scalp-vein needles and polyethylene catheters in children . J Pediatr 1972;;80:78-83.
Feigin RD, Shearer WT:  Opportunistic infection in children. I. In the compromised host . J Pediatr 1975;;87:507-514.
Feigin RD, Shearer WT:  Opportunistic infection in children. II. In the compromised host . J Pediatr 1975;;87:677-694.

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References

Kanof A, Kramer B:  Multiple invasion of the bloodstream . J Lab Clin Med 1941;;27:173-180.
Hochstein HD, Kirklan WR, Young VM:  Recovery of more than one organism in septicemias . N Engl J Med 1965;;273:468-474.
Bodey GP, Nies BA, Freireich EJ:  Multiple organism septicemia in acute leukemia . Arch Intern Med 1965;;116:267-272.
DuPont HL, Spink WW:  Infections due to gram-negative organisms: An analysis of 860 patients with bacteremia at the University of Minnesota Medical Center, 1958, 1966 . Medicine 1969;;48:307-332.
Hermans PE, Washington JA II:  Polymicrobial bacteremia . Ann Intern Med 1970;;73:387-392.
Monif GRG, Baer H:  Polymicrobial bacteremia in obstetric patients . Obstet Gynecol 1976;;48:167-169.
Kiani D, Quinn EL, Burch KH, et al:  The increasing importance of polymicrobial bacteremia . JAMA 1979;;242:1044-1047.
Mackowaik PA, Browne RH, Southern PM Jr, et al:  Polymicrobial sepsis: An analysis of 184 cases using log linear models . Am J Med Sci 1980;;280:73-80.
Todd JK, Roe MH:  Rapid detection of bacteremia by an early subculture technic . Am J Clin Pathol 1975;;64:694-699.
Lennette E, Spaulding E, Truant J: Manual of Clinical Microbiology . Washington, DC, American Society of Microbiology, 1974;.
Winchester PD, Todd JK, Roe MH:  Bacteremia in hospitalized children . AJDC 1977;; 131:753-758.
Pichichero ME, Todd JK:  Detection of neonatal bacteremia . J Pediatr 1979;;94:958-960.
Grajwer LA, Mukhopadhyay D, Grossman BJ:  Chronic polymicrobial bacteremia . Clin Pediatr 1976;;14:280-283.
Rosenfeld RG, Jameson S:  Polymicrobial bacteremia associated with pharyngotonsillitis . J Pediatr 1978;;93:251-252.
Jarvis WR, Highsmith AK, Allen JR, et al:  Polymicrobial bacteremia associated with lipid emulsion in a neonatal intensive care unit . Pediatr Infect Dis 1983;;2:203-208.
Peter G, Lloyd-Still JD, Lovejoy FH:  Local infection and bacteremia from Scalp-vein needles and polyethylene catheters in children . J Pediatr 1972;;80:78-83.
Feigin RD, Shearer WT:  Opportunistic infection in children. I. In the compromised host . J Pediatr 1975;;87:507-514.
Feigin RD, Shearer WT:  Opportunistic infection in children. II. In the compromised host . J Pediatr 1975;;87:677-694.

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