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February 1984, Vol 138, No. 2 >
Article | February 1984

Bacterial-Induced RBC Alterations Complicating Necrotizing Enterocolitis FREE

Robert W. Novak, MD
[+] Author Affiliations

Reprint requests to Department of Pathology, Childrens Hospital Medical Center, 281 Locust St, Akron, OH 44308 (Dr Novak).


Am J Dis Child. 1984;138(2):183-185. doi:10.1001/archpedi.1984.02140400065016.
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• Enzymes released from bacteria can alter the surfaces of RBCs rendering them susceptible to destruction by antibodies present in a high percentage of adult plasmas. Such RBC alterations were observed in four of 20 consecutive cases of radiologically proved necrotizing enterocolitis. Involved infants were seriously ill, three of four demonstrating bowel perforation. Bacteria of the genus Clostridium were isolated from blood or peritoneal fluid in three of four affected patients and elaborated appropriate RBC-altering enzymes in vitro. Two patients who had received plasma-containing products experienced notable hemolysis. Patients treated with washed products and plasma protein fractions lacking immunoglobulins had no hemolytic problems. The alteration of the RBC membrane is easily detected by a rapid, simple lectin agglutination test.

(AJDC 1984;138:183-185)

REFERENCES

1 +
Seges RA, Kenny A, Bird GWG, et al:  Pediatric surgical patients with severe anaerobic infection: Report of 16 T-antigen positive cases and possible hazards of blood transfusion . J Pediatr Surg 1981;;16:905-910.
2 +
Kim YD, Prakash U, Weber GF, et al:  Nature of human serum blood group T antibodies . Immunol Commun 1979;;8:397-406.
3 +
Seges R, Joller P, Bird GWG, et al:  Necrotizing enterocolitis and neuraminidase-producing bacteria . Helv Paediatr Acta 1980;;35:121-128.
4 +
Bell MJ, Ternberg JL, Feigen R, et al:  Neonatal necrotizing enterocolitis . Ann Surg 1978;;87:1-7.
5 +
Judd WJ:  The use of purified lectins in immunohematology . Transfusion 1979;;19:768-772.
6 +
Silvergleid AJ, Hafleigh EB, Harabin RM, et al:  Clinical value of washed-platelet concentrate in patients with non-hemolytic transfusion reactions . Transfusion 1977;;17:33-37.
7 +
Kleigman RM, Fanaroff AA:  Neonatal necrotizing enterocolitis: A nine-year experience . Am J Dis Child 1981;;135:603-611.
8 +
Marsh JW:  Inhibitors of T-activation in human sera . Vox Sang 1960;;5:387-391.
9 +
Kosloske AM, Ulrich JA, Hoffman H:  Fulminant necrotizing enterocolitis associated with clostridia . Lancet 1978;;2:1014-1016.

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References

1 +
Seges RA, Kenny A, Bird GWG, et al:  Pediatric surgical patients with severe anaerobic infection: Report of 16 T-antigen positive cases and possible hazards of blood transfusion . J Pediatr Surg 1981;;16:905-910.
2 +
Kim YD, Prakash U, Weber GF, et al:  Nature of human serum blood group T antibodies . Immunol Commun 1979;;8:397-406.
3 +
Seges R, Joller P, Bird GWG, et al:  Necrotizing enterocolitis and neuraminidase-producing bacteria . Helv Paediatr Acta 1980;;35:121-128.
4 +
Bell MJ, Ternberg JL, Feigen R, et al:  Neonatal necrotizing enterocolitis . Ann Surg 1978;;87:1-7.
5 +
Judd WJ:  The use of purified lectins in immunohematology . Transfusion 1979;;19:768-772.
6 +
Silvergleid AJ, Hafleigh EB, Harabin RM, et al:  Clinical value of washed-platelet concentrate in patients with non-hemolytic transfusion reactions . Transfusion 1977;;17:33-37.
7 +
Kleigman RM, Fanaroff AA:  Neonatal necrotizing enterocolitis: A nine-year experience . Am J Dis Child 1981;;135:603-611.
8 +
Marsh JW:  Inhibitors of T-activation in human sera . Vox Sang 1960;;5:387-391.
9 +
Kosloske AM, Ulrich JA, Hoffman H:  Fulminant necrotizing enterocolitis associated with clostridia . Lancet 1978;;2:1014-1016.

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