Treatment of Precocious Pseudopuberty Associated With Ovarian Cysts FREE

ELMER S. LIGHTNER, MD; ROBERT P. KELCH, MD

Am J Dis Child. 1984;138(2):126-128. doi:10.1001/archpedi.1984.02140400012002.

Text Size: A A A

Published online

Article

References

Comments

ABSTRACT

ABSTRACT | REFERENCES

Sexual precocity in girls is defined as the appearance of secondary sexual characteristics before the age of 7½ years or menstruation before 8 years of age. In this issue of the AJDC, Kosloske et al¹ have reported two cases of isosexual precocity associated with small (9 and 11 mm in diameter), unilateral ovarian cysts. Both patients had a one-month history of breast tenderness and development of 1- to 2-cm breast buds; sexual hair was not present in either case. From this limited experience, Kosloske and colleagues¹ suggest that if pelvic ultrasonography identifies an ovarian mass, either solid or cystic, and a serum estrogen level is increased, an exploratory laparotomy should be performed. Their aggressive, and we believe questionable, conclusion should challenge each of us to make every reasonable attempt to define the specific cause of the sexual precocity; otherwise, their recommendation would require surgical exploration of all patients who

REFERENCES

ABSTRACT | REFERENCES

Kosloske AM, Goldthorn JF, Kaufman E, et al: Treatment of precocious pseudopuberty associated with follicular cysts of the ovary . AJDC 1984;;138:147-149.

Lintern-Moore S, Peters H, Moore GPM, et al: Follicular development in the infant human ovary . J Reprod Fertil 1974;;39:53-64.

Lack EE, Perez-Atayde AR, Murthy ASK, et al: Granulosa theca cell tumors in premenarchal girls: A clinical and pathologic study of ten cases . Cancer 1981;;48:1846-1854.

Zaloudek C, Norris HJ: Granulosa tumors of the ovary in children . Am J Surg Pathol 1982;;6:513-522.

Hill LM, Breckle R, Coulam CB: Assessment of human follicular development by ultrasound . Mayo Clin Proc 1982;;57:176-180.

Kelch RP, Clemens LE, Markovs M, et al: Metabolism and effects of synthetic gonadotropin-releasing hormone (GnRH) in children and adults . J Clin Endocrinol Metabol 1975;;40: 53-61.

Lucky AW, Rich BH, Rosenfield RL, et al: Bioactive LH: A test to discriminate true precocious puberty from premature thelarche and adrenarche . J Pediatr 1980;;97:214-216.

Zipf WB, Kelch RP, Hopwood NJ, et al: Suppressed responsiveness to gonadotropin-releasing hormone in girls with unsustained isosexual precocity . J Pediatr 1979;;95:38-43.

Richards GE, Kaplan SL, Grumbach MM: Sexual precocity caused by ovarian follicular cysts: Spontaneous regression and recurrence with prepubertal gonadotropin levels , abstracted. Pediatr Res 1977;;11:431.

Shawker TH, Comite F, Rieth KG, et al: Ultrasonography of the female pelvis in precocious puberty , abstracted. Ultrasound Med Biol 1982;;1:28.

Evans AT, Gaffey TA, Malkasian GD, et al: Clinicopathologic review of 118 granulosa and 82 theca cell tumors . Obstet Gynecol 1980;;55:231-238.

Comite F, Cutler GB, Rivier J, et al: Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone . N Engl J Med 1981;; 305:1546-1550.

Towne BH, Mahour GH, Woolley MM, et al: Ovarian cysts and tumors in infancy and childhood . J Pediatr Surg 1975;;10:311-320.

DiGeorge AM: Albright syndrome: Is it coming of age? J Pediatr 1975;;87:1018-1020.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal