Sir.—I am interested in the study on non-A, non-B (NANB) hepatitis by Locasciulli and colleagues1 in the AJDC.
Since these investigators previously concluded that hepatitis B might influence the prognosis of childhood acute lymphoblastic leukemia,2 I would like to know the effect of NANB hepatitis.
Despite the fact that Locasciulli and co-workers' six patients had NANB-type hepatitis according to their criteria,1 the immunofluorescence pattern was different in their patients' liver specimens. Was the immunofluorescence pattern related to the histologic diagnosis of the liver? What was their explanation for the rather localized immunofluorescence pattern shown in their Figure? Was the delta antigen looked for in their patients? Did they look for this immunofluorescence pattern in the liver of leukemic patients without evidence of chronic liver disease?
In another previous study,3 these investigators concluded that "there was a significant association between HBV [hepatitis B virus] infection and