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Poland's Syndrome and Lymphoma

Am J Dis Child. 1983;137(12):1211-1212. doi:10.1001/archpedi.1983.02140380069028.
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Sir.—Having noted eight previous cases of leukemia in patients with Poland's syndrome,1-5 we thought it interesting to report a case of B-cell lymphoma of bone in a 25-year-old man with Poland's syndrome.

Our patient had congenital absence of the pectoralis major and minor muscles, as well as symbrachydactyly in the ipsilateral hand. The ipsilateral nipple was hypoplastic, and there was scoliosis toward the affected side.

The patient had a painful lesion in the upper tibia that was lytic on a roentgenogram and showed increased uptake on a bone scan. An open bone biopsy specimen with immunofluorescent antibody marker studies showed B-cell lymphoma. The metastatic workup gave normal results. The patient will undergo six courses of cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, followed by local radiation therapy.

This case once again raises the ques


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