0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Pharmacodynamics and Kinetics of Cimetidine in a Premature Newborn

JACOB V. ARANDA, MD, PHD; EUGENE W. OUTERBRIDGE, MD; JEROME J. SCHENTAG, PHARMD
Am J Dis Child. 1983;137(12):1207. doi:10.1001/archpedi.1983.02140380067025.
Text Size: A A A
Published online

Cimetidine, an H2 receptor antagonist, is currently widely used to block gastric acid secretions in adult patients with peptic ulcers and to prevent stress ulceration and subsequent bleeding in critically ill or traumatized patients.1 It has also been used in newborns,2 despite lack of information on the pharmacologic effects and kinetic disposition of this drug in this age group. We, therefore, report the plasma elimination of this drug and its effect on gastric acid secretions in a premature neonate.

Report of a Case.—A 660-g female infant was born at 25 weeks' gestation. The first three weeks of life were complicated by severe apnea, bradycardia, and respiratory distress requiring mechanical ventilation. Congestive heart failure caused by a patent ductus arteriosus was also noted; it responded to diuretics and two courses of indomethacin and chloroquine phosphate. She received total parenteral nutrition. Impaired renal function was noted, presumably caused

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();