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Isolated Corticotropin Deficiency

Am J Dis Child. 1983;137(12):1202-1203. doi:10.1001/archpedi.1983.02140380062021.
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Isolated deficiency of corticotropin is a rare disorder in childhood. Only a few cases of isolated corticotropin deficiency have been reported.1,2 Evidence for corticotropin deficiency has usually been inferred from plasma corticosteroid levels. However, the use of a radioimmunoassay (RIA) for measuring anterior pituitary hormone levels provides a technique to establish this diagnosis more accurately.

We report endocrine findings in a 6-month-old female infant with isolated corticotropin deficiency who initially had hypoglycemia in the neonatal period.

Report of a Case.—A 6-month-old female infant was admitted to our hospital for evaluation of recurrent hypoglycemia that began in the neonatal period. She was born after an uncomplicated term pregnancy with normal delivery. The Apgar score was 10 at five minutes. The birth weight was 3.7 kg, and the length was 50 cm. At 24 hours of age, the infant was lethargic, with peripheral cyanosis. Her blood glucose level was 10


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