We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Radiological Case of the Month

Thomas E. Sumner, MD; Frank M. Volberg, MD; Allen R. Chauvenet, MD; Jon S. Abramson, MD; Charles S. Turner, MD; Lionel W. Young, MD
Am J Dis Child. 1983;137(12):1193-1194. doi:10.1001/archpedi.1983.02140380053018.
Text Size: A A A
Published online


A 5-year-old boy with acute lymphocytic leukemia had his third bone marrow relapse. After initial reinduction failed, he was given aggressive reinduction chemotherapy, which led to five weeks of bone marrow hypoplasia. He had repeated high temperatures, but no pathogenic organisms grew from blood cultures. There was no clinical response to antibiotics, although there was bone marrow remission. Physical examination demonstrated hepatomegaly and upper abdominal tenderness. Scintigraphy (using gallium citrate Ga 67) of the abdomen showed normal findings. Abdominal sonography (Fig 1) and computed tomography (CT) (Fig 2) preceded exploratory laparotomy. Urine cultures eventually yielded Candida stellatoidea; additional blood cultures yielded no pathogens.

Denouement and Discussion 

Hepatic and Splenic Candidiasis in Acute Leukemia  Abdominal sonography showed splenomegaly with multiple hypoechoic areas. Several hypoechoic areas had central foci of increased echogenicity, suggesting a "bull's-eye" or "target" appearance (Fig 1). Computed tomography demonstrated well-circumscribed, low-density areas within the splenic parenchyma that


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.