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December 1983, Vol 137, No. 12 >
Article | December 1983

Uveitis Complicating Autoimmune Chronic Active Hepatitis FREE

Jeffrey N. Bloom, MD; I. Matthew Rabinowicz, MD; Stanford T. Shulman, MD
[+] Author Affiliations

Reprint requests to Suite 555, Marshall Taylor Building, 836 Prudential Dr, Jacksonville, FL 32207 (Dr Bloom).


Am J Dis Child. 1983;137(12):1175-1176. doi:10.1001/archpedi.1983.02140380035011.
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• A patient with autoimmune hepatitis B surface antigen—negative chronic active hepatitis (CAH) developed uveitis during the course of her disease. The occurrence of this eye disorder provides additional support for an autoimmune pathogenesis for CAH. Clinicians should be alert to the association of uveitis with CAH, so that patients at risk may be examined for this potentially serious ocular disease.

(Am J Dis Child 1983;137:1175-1176)

REFERENCES

1 +
Klatskin G:  Persistent HB antigenemia: Associated clinical manifestations and hepatic lesions . Am J Med Sci 1975;;270:33-40.
2 +
Sherlock S: Chronic Hepatitis: Diseases of the Liver and Biliary System , ed 5. Oxford, England, Blackwell Scientific Publications, 1975;, pp 403-404.
3 +
Plotz PH:  Autoimmunity in hepatitis . Med Clin North Am 1975;;59:869-876.
4 +
Shulman ST, Hutto JH Jr, Ayoub EM, et al:  Double-blind evaluation of transfer factor therapy of HBsAg-positive chronic aggressive hepatitis: Preliminary report of efficacy . Cell Immunol 1979;;43:352-361.
5 +
Daum F, Gould HB, Gold D, et al:  Asymptomatic transient uveitis in children with inflammatory bowel disease . Am J Dis Child 1979;;133: 170-171.
6 +
Hopf U, Meyer zum Büschenfeld K, Arnold W:  Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis . N Engl J Med 1976;;294:578-582.
7 +
Jensen DM, McFarlane IG, Portmann BS, et al:  Antibodies against a liver membrane antigen in acute and chronic hepatitis . N Engl J Med 1978;;299:1-7.
8 +
Ammann AJ, Hong R:  Selective IgA deficiency: Presentation of 30 cases and a review of the literature . Medicine 1971;;50:223-236.
9 +
Epstein WV, Tan M, Easterbrook M:  Serum antibody to double-stranded RNA and DNA in patients with idiopathic and secondary uveitis . N Engl J Med 1971;;285:1502-1506.
10 +
Burns RM, Rheins MS, Suie T:  Anti-DNA in the sera of patients with uveitis . Arch Ophthalmol 1967;;77:777-779.
11 +
Rahi AHS, Holborow EJ, Perkins ES, et al:  Immunological investigations in uveitis . Trans Ophthalmol Soc UK 1976;;96:113-122.
12 +
Feinberg EB, Shore B, Leopold IH, et al:  Cellular immunity in chronc ophthalmic disorders . Am J Ophthalmol 1972;;73:68-71.
13 +
Duke-Elder S (ed): Diseases of the Uveal Tract: System of Ophthalmology . London, Henry Kimpton Publishers Ltd, 1966;, vol 9, p 358.
14 +
Schlaegel TF: Essentials of Uveitis . Boston, Little Brown & Co, 1969;, p 2.
15 +
Schlaegel TF:  Miscellaneous uveitis syndromes , in Duane TD (ed): Clincal Ophthalmology . Hagerstown, Md, Harper & Row Publishers Inc, 1982;, vol 4, chap 57, p 11.
16 +
Key SN, Kimura SJ:  Iridocyclitis associated with juvenile rheumatoid arthritis . Am J Ophthalmol 1975;;80:425-429.

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References

1 +
Klatskin G:  Persistent HB antigenemia: Associated clinical manifestations and hepatic lesions . Am J Med Sci 1975;;270:33-40.
2 +
Sherlock S: Chronic Hepatitis: Diseases of the Liver and Biliary System , ed 5. Oxford, England, Blackwell Scientific Publications, 1975;, pp 403-404.
3 +
Plotz PH:  Autoimmunity in hepatitis . Med Clin North Am 1975;;59:869-876.
4 +
Shulman ST, Hutto JH Jr, Ayoub EM, et al:  Double-blind evaluation of transfer factor therapy of HBsAg-positive chronic aggressive hepatitis: Preliminary report of efficacy . Cell Immunol 1979;;43:352-361.
5 +
Daum F, Gould HB, Gold D, et al:  Asymptomatic transient uveitis in children with inflammatory bowel disease . Am J Dis Child 1979;;133: 170-171.
6 +
Hopf U, Meyer zum Büschenfeld K, Arnold W:  Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis . N Engl J Med 1976;;294:578-582.
7 +
Jensen DM, McFarlane IG, Portmann BS, et al:  Antibodies against a liver membrane antigen in acute and chronic hepatitis . N Engl J Med 1978;;299:1-7.
8 +
Ammann AJ, Hong R:  Selective IgA deficiency: Presentation of 30 cases and a review of the literature . Medicine 1971;;50:223-236.
9 +
Epstein WV, Tan M, Easterbrook M:  Serum antibody to double-stranded RNA and DNA in patients with idiopathic and secondary uveitis . N Engl J Med 1971;;285:1502-1506.
10 +
Burns RM, Rheins MS, Suie T:  Anti-DNA in the sera of patients with uveitis . Arch Ophthalmol 1967;;77:777-779.
11 +
Rahi AHS, Holborow EJ, Perkins ES, et al:  Immunological investigations in uveitis . Trans Ophthalmol Soc UK 1976;;96:113-122.
12 +
Feinberg EB, Shore B, Leopold IH, et al:  Cellular immunity in chronc ophthalmic disorders . Am J Ophthalmol 1972;;73:68-71.
13 +
Duke-Elder S (ed): Diseases of the Uveal Tract: System of Ophthalmology . London, Henry Kimpton Publishers Ltd, 1966;, vol 9, p 358.
14 +
Schlaegel TF: Essentials of Uveitis . Boston, Little Brown & Co, 1969;, p 2.
15 +
Schlaegel TF:  Miscellaneous uveitis syndromes , in Duane TD (ed): Clincal Ophthalmology . Hagerstown, Md, Harper & Row Publishers Inc, 1982;, vol 4, chap 57, p 11.
16 +
Key SN, Kimura SJ:  Iridocyclitis associated with juvenile rheumatoid arthritis . Am J Ophthalmol 1975;;80:425-429.

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