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Disseminated Parainfluenza Infection in a Child With Severe Combined Immunodeficiency

John A. Frank Jr, MD; Robert W. Warren, MD; J. Allan Tucker, MD; Joan Zeller, MS; Catherine M. Wilfert, MD
Am J Dis Child. 1983;137(12):1172-1174. doi:10.1001/archpedi.1983.02140380032010.
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• An 8-month-old male infant with severe combined immunodeficiency syndrome was admitted to the hospital with pneumonitis and, subsequently, died at 21 months of age. During his lengthy hospitalization, parainfluenza virus type 3 (PIV-3) was isolated from respiratory secretions and unusual sites, such as pericardial fluid, CSF, and WBCs. A postmortem examination showed apparent viral pancreatitis, and PIV-3 was isolated from the lung, brain, and pericardial fluid. To our knowledge, this is the first reported case of disseminated parainfluenza infection identified during life. We speculated that a mutant fusion protein may have been elaborated by the virus, allowing dissemination beyond the respiratory tract.

(Am J Dis Child 1983;137:1172-1174)


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