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December 1983, Vol 137, No. 12 >
Article | December 1983

Nifedipine in Hypertensive Emergencies of Children FREE

Uǧur Dilmen, MD; M. Kazim Çaǧlar, MD; D. Ali Şenses, MD; Erol Kinik, MD
[+] Author Affiliations

Reprint requests to Hacettepe Children's Hospital, Ankara, Turkey (Dr Dilmen).


Am J Dis Child. 1983;137(12):1162-1165. doi:10.1001/archpedi.1983.02140380022007.
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References
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• We studied the acute antihypertensive effect of sublingually administered nifedipine in 21 patients with different clinical diagnoses. Nifedipine lowered systolic and diastolic BP from 181 ± 18 and 136 ± 21 mm Hg to 132 ± 15 and 98 ± 17 mm Hg, respectively, after 30 minutes, and produced a slight increase in heart rate. This is the first known study of administration of nifedipine for acute hypertension in children.

(Am J Dis Child 1983;137:1162-1165)

REFERENCES

1 +
Braunwald E:  Mechanism of action of calcium-channel blocking agents . N Engl J Med 1982;;307:1618-1627.
2 +
Aoki K, Kondo S, Mochizuki A, et al:  Antihypertensive effect of cardiovascular Ca++ antagonist in hypertensive patients in the absence and presence of beta-adrenergic blockade . Am Heart J 1978;;96:218-226.
3 +
Lederballe Pederson O, Mikkelsen E:  Acute and chronic effects of nifedipine in arterial hypertension . Eur J Clin Pharmacol 1978;;14:375-381.
4 +
Kambara H, Fujimoto K, Wakabayashi A, et al:  Primary pulmonary hypertension: Beneficial therapy with diltiazem . Am Heart J 1981;;101: 230-231.
5 +
Stone PH, Muller JE:  Nifedipine therapy for recurrent ischemic pain following myocardial infarction . Clin Cardiol 1982;;5:223-230.
6 +
Deanfield J, Wright C, Fox K:  Treatment of angina pectoris with nifedipine: Importance of dose titration . Br Med J 1983;;286:1467-1471.
7 +
Matsumoto S, Ito T, Sada T, et al:  Hemodynamic effects of nifedipine in congestive heart failure . Am J Cardiol 1980;;46:476-480.
8 +
Klugmann S, Salvi A, Camerini F:  Haemodynamic effects of nifedipine in heart failure . Br Heart J 1980;;43:440-446.
9 +
Lorell BH, Paulus WJ, Grossman W, et al:  Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy . Circulation 1982;; 65:499-507.
10 +
Rodeheffer RJ, Rommer JA, Wigley F, et al:  Controlled double-blind trial of nifedipine in the treatment of Raynaud's phenomenon . N Engl J Med 1983;;308:880-883.
11 +
Bertel O, Conen D, Radu EW, et al:  Nifedipine in hypertensive emergencies . Br Med J 1983;;286:19-21.
12 +
Guazzi M, Olivari MT, Polese A, et al:  Nifedipine a new antihypertensive with rapid action . Clin Pharmacol Ther 1977;;22:528-532.
13 +
Beer H, Callegas I, Cohen A, et al:  Efficacy of sublingual nifedipine in the acute treatment of systemic hypertension . Chest 1981;;79: 571-574.
14 +
Husted SE, Kreammer Nielsen H, Christensen CK, et al:  Long term therapy of arterial hypertension with nifedipine given alone or in combination with a beta-adrenoreceptor blocking agent . Eur J Clin Pharmacol 1982;;22:101-103.
15 +
Ganong WF: Review of Medical Physiology , Los Altos, Calif, Lange Medical Publications, 1981;, pp 43-59.
16 +
Kohlhardt M, Bauer B, Krause H, et al:  New selective inhibitors of the transmembrane Ca conductivity in mammalian myocardial fibres: Studies with the voltage clamp technique . Experientia 1972;;28:288-289.
17 +
Braunwald E:  Calcium channel blockers: Pharmacologic considerations . Am Heart J 1982;; 104:665-671.
18 +
Rowland E, Evans T, Krikler D:  Effect of nifedipine on atrioventricular conduction as compared with verapamil: Intracardiac electrophysiological study . Br Heart J 1979;;42:124-127.
19 +
Horster FA:  Pharmacokinetics of nifedipine-14C in man , in Hashimoto K, Kimura E, Kobayashi T (eds): First International Nifedipine (Adalat) Symposium . Tokyo, University of Tokyo Press, 1975;, pp 67-70.
20 +
Braasch W, Ebner F:  Long-term treatment with nifedipine , in Hashimoto K, Kimura E, Kobayashi T, eds: First International Nifedipine (Adalat) Symposium . Tokyo, University of Tokyo Press, 1975;, pp 200-204.
21 +
Hayase S, Hirakawa S, Hosokawa S, et al:  Therapeutic efficacy: Clinical and basic hemodynamic studies on nifedipine , in Hashimoto K, Kimura E, Kobayashi T (eds): First International Nifedipine (Adalat) Symposium . Tokyo, University of Tokyo Press, 1975;, pp 77-83.
22 +
Bertel O, Buhler FR, Kiowski W, et al:  Decreased beta-adrenoreceptor responsiveness as related to age, blood pressure and plasma catecholamines in patients with essential hypertension . Hypertension 1980;;2:130-138.

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References

1 +
Braunwald E:  Mechanism of action of calcium-channel blocking agents . N Engl J Med 1982;;307:1618-1627.
2 +
Aoki K, Kondo S, Mochizuki A, et al:  Antihypertensive effect of cardiovascular Ca++ antagonist in hypertensive patients in the absence and presence of beta-adrenergic blockade . Am Heart J 1978;;96:218-226.
3 +
Lederballe Pederson O, Mikkelsen E:  Acute and chronic effects of nifedipine in arterial hypertension . Eur J Clin Pharmacol 1978;;14:375-381.
4 +
Kambara H, Fujimoto K, Wakabayashi A, et al:  Primary pulmonary hypertension: Beneficial therapy with diltiazem . Am Heart J 1981;;101: 230-231.
5 +
Stone PH, Muller JE:  Nifedipine therapy for recurrent ischemic pain following myocardial infarction . Clin Cardiol 1982;;5:223-230.
6 +
Deanfield J, Wright C, Fox K:  Treatment of angina pectoris with nifedipine: Importance of dose titration . Br Med J 1983;;286:1467-1471.
7 +
Matsumoto S, Ito T, Sada T, et al:  Hemodynamic effects of nifedipine in congestive heart failure . Am J Cardiol 1980;;46:476-480.
8 +
Klugmann S, Salvi A, Camerini F:  Haemodynamic effects of nifedipine in heart failure . Br Heart J 1980;;43:440-446.
9 +
Lorell BH, Paulus WJ, Grossman W, et al:  Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy . Circulation 1982;; 65:499-507.
10 +
Rodeheffer RJ, Rommer JA, Wigley F, et al:  Controlled double-blind trial of nifedipine in the treatment of Raynaud's phenomenon . N Engl J Med 1983;;308:880-883.
11 +
Bertel O, Conen D, Radu EW, et al:  Nifedipine in hypertensive emergencies . Br Med J 1983;;286:19-21.
12 +
Guazzi M, Olivari MT, Polese A, et al:  Nifedipine a new antihypertensive with rapid action . Clin Pharmacol Ther 1977;;22:528-532.
13 +
Beer H, Callegas I, Cohen A, et al:  Efficacy of sublingual nifedipine in the acute treatment of systemic hypertension . Chest 1981;;79: 571-574.
14 +
Husted SE, Kreammer Nielsen H, Christensen CK, et al:  Long term therapy of arterial hypertension with nifedipine given alone or in combination with a beta-adrenoreceptor blocking agent . Eur J Clin Pharmacol 1982;;22:101-103.
15 +
Ganong WF: Review of Medical Physiology , Los Altos, Calif, Lange Medical Publications, 1981;, pp 43-59.
16 +
Kohlhardt M, Bauer B, Krause H, et al:  New selective inhibitors of the transmembrane Ca conductivity in mammalian myocardial fibres: Studies with the voltage clamp technique . Experientia 1972;;28:288-289.
17 +
Braunwald E:  Calcium channel blockers: Pharmacologic considerations . Am Heart J 1982;; 104:665-671.
18 +
Rowland E, Evans T, Krikler D:  Effect of nifedipine on atrioventricular conduction as compared with verapamil: Intracardiac electrophysiological study . Br Heart J 1979;;42:124-127.
19 +
Horster FA:  Pharmacokinetics of nifedipine-14C in man , in Hashimoto K, Kimura E, Kobayashi T (eds): First International Nifedipine (Adalat) Symposium . Tokyo, University of Tokyo Press, 1975;, pp 67-70.
20 +
Braasch W, Ebner F:  Long-term treatment with nifedipine , in Hashimoto K, Kimura E, Kobayashi T, eds: First International Nifedipine (Adalat) Symposium . Tokyo, University of Tokyo Press, 1975;, pp 200-204.
21 +
Hayase S, Hirakawa S, Hosokawa S, et al:  Therapeutic efficacy: Clinical and basic hemodynamic studies on nifedipine , in Hashimoto K, Kimura E, Kobayashi T (eds): First International Nifedipine (Adalat) Symposium . Tokyo, University of Tokyo Press, 1975;, pp 77-83.
22 +
Bertel O, Buhler FR, Kiowski W, et al:  Decreased beta-adrenoreceptor responsiveness as related to age, blood pressure and plasma catecholamines in patients with essential hypertension . Hypertension 1980;;2:130-138.

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