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October 1983, Vol 137, No. 10 >
Article | October 1983

Precocious Puberty and Chronic Renal Failure FREE

Mitchell E. Geffner, MD; Solomon A. Kaplan, MD; Barbara M. Lippe, MD; Richard N. Fine, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, UCLA Medical Center, Los Angeles, CA 90024 (Dr Geffner).


Am J Dis Child. 1983;137(10):956-958. doi:10.1001/archpedi.1983.02140360020007.
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• A 7½-year-old boy with chronic renal failure (CRF) experienced transient central isosexual precocious puberty. Simultaneously, he demonstrated hyperprolactinemia with galactorrhea and apparent secondary or tertiary hypothyroidism. These findings could have been a consequence of an unexplained hypothalamic dysregulation. During this period, marked linear growth ensued (8.7 cm during nine months) associated with rapid bone age advancement (four years during a 21-month period). Whereas most boys with CRF demonstrate delayed pubertal development and suppressed linear growth, our patient's transient condition demonstrated that both growth and puberty can occur in the presence of uremia.

(Am J Dis Child 1983;137:956-958)

REFERENCES

1 +
Ferraris J, Saenger P, Levine L, et al:  Delayed puberty in males with chronic renal failure . Kidney Int 1980;;18:344-350.
2 +
Broyer M, Kleinknecht C, Loirat C, et al:  Growth in children treated with long-term hemodialysis . J Pediatr 1974;;84:642-649.
3 +
Baum M, Powell D, Calvin S, et al:  Continuous ambulatory peritoneal dialysis in children: Comparison with hemodialysis . N Engl J Med 1982;;307:1537-1542.
4 +
Holdsworth S, Atkins RC, de Kretser DM:  The pituitary-testicular axis in men with chronic renal failure . N Engl J Med 1977;;296:1245-1249.
5 +
Stewart-Bentley M, Gans D, Horton R:  Regulation of gonadal function in uremia . Metabolism 1974;;23:1065-1072.
6 +
Mastrogiacomo I, Feghali V, De Besi L, et al:  Prolactin, gonadotropins, testosterone, and estrogens in uremic men undergoing hemodialysis . Arch Androl 1982;;9:279-282.
7 +
Penny R:  Disorders of the testis , in Kaplan SA (ed): Clinical and Adolescent Endocrinology . Philadelphia, WB Saunders Co, 1982;, p 312.
8 +
Rauh W: Endocrine function in children with ESRD, in Fine RN, Gruskin AB (eds): End-Stage Renal Disease in Children. Philadelphia, WB Saunders Co, in press.
9 +
Cowden EA, Ratcliffe WA, Ratcliffe JG, et al:  Hyperprolactinaemia in renal disease . Clin Endocrinol 1978;;9:241-248.
10 +
Czernichow P, Dauzet MC, Broyer M, et al:  Abnormal TSH, PRL, and GH response to TSH releasing factor in chronic renal failure . J Clin Endocrinol Metabol 1976;;43:630-637.
11 +
Feldman HA, Singer I:  Endocrinology and metabolism in uremia and dialysis: A clinical review . Medicine 1974;;54:345-376.
12 +
Steiner J, Cassar J, Mashiter K, et al:  Effects of methyldopa on prolactin and growth hormone . Br Med J 1976;;1:1186-1188.
13 +
Wassner SJ, Buckingham BA, Kershnar AJ, et al:  Thyroid function in children with chronic renal failure . Nephron 1977;;19:236-241.
14 +
Semple CG, Beastall GH, Henderson IJ, et al:  Thyroid function and continuous ambulatory peritoneal dialysis . Nephron 1982;;32:249-252.
15 +
Hemady ZS, Siler-Khodr TM, Najjar S:  Precocious puberty in juvenile hypothyroidism . J Pediatr 1978;;92:55-59.
16 +
Chopra IJ, Chopra U, Smith SR, et al:  Reciprocal changes in serum concentrations of 3,3′,5-triiodothyronine (T3) in systemic illnesses . J Clin Endocrinol Metabol 1975;;41:1043-1049.
17 +
Semple CG, Beastall GH, Henderson IJ, et al:  The pituitary-testicular axis of uraemic subjects on haemodialysis and continuous ambulatory peritoneal dialysis . Acta Endocrinol 1982;; 101:464-467.
18 +
Jones RWA, El Bishti MM, Bloom SR, et al:  The effects of anabolic steroids on growth, body composition, and metabolism in boys with chronic renal failure on regular hemodialysis . J Pediatr 1980;;97:559-566.
19 +
Kaplan SA, Ling SM, Irani NG:  Idiopathic isosexual precocity: Therapy with medroxyprogesterone . Am J Dis Child 1968;;116:591-598.

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References

1 +
Ferraris J, Saenger P, Levine L, et al:  Delayed puberty in males with chronic renal failure . Kidney Int 1980;;18:344-350.
2 +
Broyer M, Kleinknecht C, Loirat C, et al:  Growth in children treated with long-term hemodialysis . J Pediatr 1974;;84:642-649.
3 +
Baum M, Powell D, Calvin S, et al:  Continuous ambulatory peritoneal dialysis in children: Comparison with hemodialysis . N Engl J Med 1982;;307:1537-1542.
4 +
Holdsworth S, Atkins RC, de Kretser DM:  The pituitary-testicular axis in men with chronic renal failure . N Engl J Med 1977;;296:1245-1249.
5 +
Stewart-Bentley M, Gans D, Horton R:  Regulation of gonadal function in uremia . Metabolism 1974;;23:1065-1072.
6 +
Mastrogiacomo I, Feghali V, De Besi L, et al:  Prolactin, gonadotropins, testosterone, and estrogens in uremic men undergoing hemodialysis . Arch Androl 1982;;9:279-282.
7 +
Penny R:  Disorders of the testis , in Kaplan SA (ed): Clinical and Adolescent Endocrinology . Philadelphia, WB Saunders Co, 1982;, p 312.
8 +
Rauh W: Endocrine function in children with ESRD, in Fine RN, Gruskin AB (eds): End-Stage Renal Disease in Children. Philadelphia, WB Saunders Co, in press.
9 +
Cowden EA, Ratcliffe WA, Ratcliffe JG, et al:  Hyperprolactinaemia in renal disease . Clin Endocrinol 1978;;9:241-248.
10 +
Czernichow P, Dauzet MC, Broyer M, et al:  Abnormal TSH, PRL, and GH response to TSH releasing factor in chronic renal failure . J Clin Endocrinol Metabol 1976;;43:630-637.
11 +
Feldman HA, Singer I:  Endocrinology and metabolism in uremia and dialysis: A clinical review . Medicine 1974;;54:345-376.
12 +
Steiner J, Cassar J, Mashiter K, et al:  Effects of methyldopa on prolactin and growth hormone . Br Med J 1976;;1:1186-1188.
13 +
Wassner SJ, Buckingham BA, Kershnar AJ, et al:  Thyroid function in children with chronic renal failure . Nephron 1977;;19:236-241.
14 +
Semple CG, Beastall GH, Henderson IJ, et al:  Thyroid function and continuous ambulatory peritoneal dialysis . Nephron 1982;;32:249-252.
15 +
Hemady ZS, Siler-Khodr TM, Najjar S:  Precocious puberty in juvenile hypothyroidism . J Pediatr 1978;;92:55-59.
16 +
Chopra IJ, Chopra U, Smith SR, et al:  Reciprocal changes in serum concentrations of 3,3′,5-triiodothyronine (T3) in systemic illnesses . J Clin Endocrinol Metabol 1975;;41:1043-1049.
17 +
Semple CG, Beastall GH, Henderson IJ, et al:  The pituitary-testicular axis of uraemic subjects on haemodialysis and continuous ambulatory peritoneal dialysis . Acta Endocrinol 1982;; 101:464-467.
18 +
Jones RWA, El Bishti MM, Bloom SR, et al:  The effects of anabolic steroids on growth, body composition, and metabolism in boys with chronic renal failure on regular hemodialysis . J Pediatr 1980;;97:559-566.
19 +
Kaplan SA, Ling SM, Irani NG:  Idiopathic isosexual precocity: Therapy with medroxyprogesterone . Am J Dis Child 1968;;116:591-598.

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