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July 1983, Vol 137, No. 7 >
Article | July 1983

Severe Hypernatremia in Cystic Fibrosis FREE

JOHN R. CARLILE, MD; DIANE M. PAFFORD, MPH, RD; WILLIAM W. WARING, MD
Am J Dis Child. 1983;137(7):702-703. doi:10.1001/archpedi.1983.02140330084024.
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The sweat of patients with cystic fibrosis (CF) has elevated levels of sodium and chloride compared with that of nonaffected persons. The quantities of electrolytes lost in sweat may be of considerable magnitude,1,2 and are dependent on sweat electrolyte concentration and volume.

Frequently observed hypochloremia in patients with CF living in the New Orleans area necessitates the use of salt supplementation. Excessive supplementation resulted in life-threatening hypernatremia in one patient. We wish to alert physicians to this complication of salt supplementation. Additionally, we polled all designated CF centers to determine a consensus regarding the practice of salt supplementation.

Responses From 51 CF Centers on Recommended Daily Amount of Salt Supplementation for Infants* Response No. of Centers Amount not specified† 25 1 g/day 11 1-2 g/day 5 0.5-1 g/day 3 Determined by serum electrolytes 3 1 mEq/kg/day 1 2-3 times maintenance sodium 1 Equal to maintenance sodium 1 "Pinch," ie,

REFERENCES

1 +
Rendle-Short J:  Fibrocystic disease of the pancreas presenting with acute salt depletion . Arch Dis Child 1956;;31:23-30.
Link to Article
2 +
Kessler WR, Andersen DH:  Heat prostration in fibrocystic disease of the pancreas and other conditions . Pediatrics 1951;;8:648-656.
3 +
Finberg L, Kiley J, Luttrell CN:  Mass accidental salt poisoning in infancy . JAMA 1963;;184: 187-190.
Link to Article
4 +
Arvanitakis SN, Lobeck CC:  Metabolic alkalosis and salt depletion in cystic fibrosis . J Pediatr 1973;;82:535-536.
Link to Article
5 +
Gottlieb RP:  Metabolic alkalosis in cystic fibrosis . J Pediatr 1971;;79:930-936.
Link to Article
6 +
Beckerman RC, Taussig LM:  Hypoelectrolytemia and metabolic alkalosis in infants with cystic fibrosis . Pediatrics 1979;;63:580-583.
7 +
Waring WW:  Current management of cystic fibrosis , in Barnes LS (ed): Advances in Pediatrics . Chicago, Year Book Medical Publishers Inc, 1976;, p 401.
8 +
Winters RW:  Maintenance fluid therapy , in Winters RW (ed): The Body Fluids in Pediatrics . Boston, Little Brown & Co, 1973;, p 113.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Rendle-Short J:  Fibrocystic disease of the pancreas presenting with acute salt depletion . Arch Dis Child 1956;;31:23-30.
Link to Article
2 +
Kessler WR, Andersen DH:  Heat prostration in fibrocystic disease of the pancreas and other conditions . Pediatrics 1951;;8:648-656.
3 +
Finberg L, Kiley J, Luttrell CN:  Mass accidental salt poisoning in infancy . JAMA 1963;;184: 187-190.
Link to Article
4 +
Arvanitakis SN, Lobeck CC:  Metabolic alkalosis and salt depletion in cystic fibrosis . J Pediatr 1973;;82:535-536.
Link to Article
5 +
Gottlieb RP:  Metabolic alkalosis in cystic fibrosis . J Pediatr 1971;;79:930-936.
Link to Article
6 +
Beckerman RC, Taussig LM:  Hypoelectrolytemia and metabolic alkalosis in infants with cystic fibrosis . Pediatrics 1979;;63:580-583.
7 +
Waring WW:  Current management of cystic fibrosis , in Barnes LS (ed): Advances in Pediatrics . Chicago, Year Book Medical Publishers Inc, 1976;, p 401.
8 +
Winters RW:  Maintenance fluid therapy , in Winters RW (ed): The Body Fluids in Pediatrics . Boston, Little Brown & Co, 1973;, p 113.

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