• The relationships between selected obstetric factors and the occurrence of periventricular-intraventricular hemorrhage (PIH) was studied in a group of 77 infants weighing 1,200 g or less at birth. The diagnosis of PIH was made using ultrasonography or at autopsy in 42 (55%) of these infants. Univariate associations between PIH and gestational age (<30 weeks), duration of labor (≥six hours), and vaginal delivery were found. Multivariate analysis, however, did not substantiate an association between PIH and any single obstetric factor. Log-linear analysis of multiway frequency tables showed significant second-order associations of PIH with gestational age and presentation during delivery and with duration of labor and presentation. A model for the risk of PIH based on gestational age, presentation, and duration of labor was derived using stepwise logistic regression. This model correctly predicted PIH in 70% (55) of the infants. Although obstetric factors may have a role in the pathogenesis of PIH, the interactions among factors, rather than single factors alone, are important.
(Am J Dis Child 1983;137:678-681)