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Angiofollicular Lymph Node Hyperplasia Causing a Neck Mass in Nail-Patella Syndrome

Am J Dis Child. 1983;137(5):498. doi:10.1001/archpedi.1983.02140310076020.
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The differential diagnosis of an enlarging neck mass in a child includes the cystic congenital anomalies, solid tumors of a variety of tissue origins, and the numerous infectious causes of regional lymphadenopathy.1

We report a case of angiofollicular lymph node hyperplasia (Castleman's disease, giant lymph node hyperplasia) as the cause of a cervical mass in a boy with nail-patella syndrome.2

Report of a Case.—A previously healthy 11-year-old boy was referred to the University of Minnesota Hospitals for examination of an enlarging mass in the neck that had been noted by the patient's mother four weeks before admission. He denied any cough, sore throat, rhinorrhea, pain, fever, chills, night sweats, weight loss, respiratory embarrassment, change in voice, recent exposure to vaccines, or infectious disease. Medical history was remarkable for mechanical orthopedic manipulation of his feet at an early age for talipes equinovarus deformities. The patient's father reportedly had


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