0
Article |

Neutrophil Function in a Patient With Meningococcal Meningitis and C7 Deficiency

CHARLES A. DAVIS, MD; SUSAN B. SHURIN, MD; KENTON PATE, MD; BLAISE L. CONGENI, MD
Am J Dis Child. 1983;137(4):404-406. doi:10.1001/archpedi.1983.02140300082026.
Text Size: A A A
Published online

Deficiency of one or more of the late components of complement (C5, C6, C7, and C8) in patients with recurrent neisserial infections is being recognized with increasing frequency.1,2 Peculiar to persons with such deficiencies is the onset of neisserial infections in adolescence and adulthood. More than half of the complement-deficient subjects discovered through family screening studies have never experienced infectious complications.1,3 Several studies have established that adding the missing complement component to the serum obtained from these patients restores the ability of their serum tc killNeisseria.2,4,5 To our knowledge, there have been no reports of the ability of neutrophils obtained from patients with deficiencies of the late complement components to ingest and kill bacteria. We recently had the opportunity to study a teenage girl with C7 deficiency who had recurrent meningococcal meningitis. Her neutrophil phagocytosis and oxidative metabolism (nitroblue tetrazolium [NBT] reduction) were assessed to determine

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();